Lidocaine/β-cyclodextrin inclusion complex as drug delivery system

被引：0
|
作者：
机构：
[1] Abou-Okeil, A.
[2] Rehan, M.
[3] El-Sawy, S.M.
[4] El-bisi, M.K.
[5] Ahmed-Farid, O.A.
[6] Abdel-Mohdy, F.A.
来源：
Abou-Okeil, A. (aokeil2004@yahoo.com) | 1600年 / Elsevier Ltd卷 / 108期
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Lidocaine (LC)/β-cyclodextrin (β-CD) inclusion complex was prepared. This complex was confirmed using, UV–vis spectroscopy, Fourier-transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA) and scanning electron microscope (SEM). This complex was used to prepare hydrogel to be used as topical pain relief. (GII) and compared with gel contains Lidocaine (GI) only. The prepared gel was evaluated by measuring the spreadability, moisture regain, viscosity, pH and drug release profile. The results received showed that the gel properties were improved by introducing the Lidocaine/β-cyclodextrin inclusion complex. The release profiles revealed that, gel with Lidocaine/β-cyclodextrin inclusion complex showed improved sustained release behaviour. © 2018 Elsevier Ltd
引用
收藏
相关论文
共 50 条
  • [1] Lidocaine/β-cyclodextrin inclusion complex as drug delivery system
    Abou-Okeil, A.
    Rehan, M.
    El-Sawy, S. M.
    El-bisi, M. K.
    Ahmed-Farid, O. A.
    Abdel-Mohdy, F. A.
    EUROPEAN POLYMER JOURNAL, 2018, 108 : 304 - 310
  • [2] Inclusion complex of methyl-β-cyclodextrin and olanzapine as potential drug delivery system for schizophrenia
    de Freitas, Marcia Rocha
    Rolim, Larissa Araujo
    de La Roca Soares, Monica Felts
    Rolim-Neto, Pedro Jose
    de Albuquerque, Miracy Muniz
    Soares-Sobrinho, Jose Lamartine
    CARBOHYDRATE POLYMERS, 2012, 89 (04) : 1095 - 1100
  • [3] Cyclodextrin/Diacerein Inclusion Complex: a Tool for Therapeutic Drug Delivery
    Petralito, Stefania
    Zanardi, Iacopo
    Memoli, Adriana
    Annesini, M. Cristina
    Travagli, Valter
    ICHEAP-10: 10TH INTERNATIONAL CONFERENCE ON CHEMICAL AND PROCESS ENGINEERING, PTS 1-3, 2011, 24 : 967 - +
  • [4] Eucalyptol/β-cyclodextrin inclusion complex loaded gellan/PVA nanofibers as antifungal drug delivery system
    Mishra, Purusottam
    Gupta, Payal
    Srivastava, Amit Kumar
    Poluri, Krishna Mohan
    Prasad, Ramasare
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 609
  • [5] Sulfisoxazole/cyclodextrin inclusion complex incorporated in electrospun hydroxypropyl cellulose nanofibers as drug delivery system
    Aytac, Zeynep
    Sen, Huseyin Sener
    Durgun, Engin
    Uyar, Tamer
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2015, 128 : 331 - 338
  • [6] Development of ferulic acid/cyclodextrin inclusion complex nanofibers for fast -dissolving drug delivery system
    Celebioglu, Asli
    Uyar, Tamer
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 584
  • [7] Characterization of lidocaine:hydroxypropyl-β-cyclodextrin inclusion complex
    Carolina Morales Moraes
    Priscila Abrami
    Daniele Riberio de Araujo
    Angélica F. A. Braga
    Michelle Georges Issa
    Humberto G. Ferraz
    Eneida de Paula
    Leonardo Fernandes Fraceto
    Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2007, 57 : 313 - 316
  • [8] Characterization of lidocaine:hydroxypropyl-β-cyclodextrin inclusion complex
    Moraes, Carolina Morales
    Abrami, Priscila
    de Araujo, Daniele Riberio
    Braga, Angelica F. A.
    Issa, Michelle Georges
    Ferraz, Humberto G.
    de Paula, Eneida
    Fraceto, Leonardo Fernandes
    JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2007, 57 (1-4) : 313 - 316
  • [9] Drug delivery system based on cyclodextrin-naproxen inclusion complex incorporated in electrospun polycaprolactone nanofibers
    Canbolat, M. Fatih
    Celebioglu, Asli
    Uyar, Tamer
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2014, 115 : 15 - 21
  • [10] Formulation of a fast-disintegrating drug delivery system from cyclodextrin/naproxen inclusion complex nanofibrous films
    Celebioglu, Asli
    Dash, Kareena
    Aboelkheir, Mahmoud
    Kilic, Mehmet E.
    Durgun, Engin
    Uyar, Tamer
    RSC MEDICINAL CHEMISTRY, 2024, 15 (02): : 595 - 606
12345