Research advances on the carboxylation of terminal alkynes with CO2

被引：0
作者：
Li M. [1 ,2 ]
Zhang L. [2 ]
Zhang A. [1 ]
Zhao Y. [2 ]
Sun N. [2 ]
Wei W. [2 ]
机构：
[1] School of Materials Science & Engineering, Shanghai University, Shanghai
[2] CAS Key Laboratory of Low-Carbon Conversion Science and Engineering, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai
来源：
Huagong Jinzhan/Chemical Industry and Engineering Progress | 2021年 / 40卷 / 06期
关键词：
C-H carboxylation; Carbon dioxide; Catalyst; Propionic acid; Terminal alkynes;
D O I：
10.16085/j.issn.1000-6613.2020-1446
中图分类号：
学科分类号：
摘要：
Propiolic acid compounds are a kind of organic intermediates which are widely used. Using CO2 as a carboxylation reagent and insert it into the C-H(sp) bond of terminal alkynes is a new route to prepare propiolic acids, which is more environmentally friendly than traditional methods. In this paper, based on systematic analysis of the reaction mechanism, research progress of the catalytic system of the CO2-based synthesis of propiolic acid was summarized, and some prospective studies closely related to the practical application of the reaction were introduced. Based on the above summary, we think that the following research should be carried out in future works: ①designing the catalyst from the perspective of actual working conditions (resistant to strong alkaline reaction system and strong polar solvent, etc.); ②strengthening the research on reaction mechanism, clarifying the differences on reaction path and intermediate structure for different catalysts, so as to consolidate the theoretical basis; ③seeking to solve potential technical bottlenecks, especially humidity sensitivity, cycling and re-use of the alkali additives, and coupling with downstream synthesis network, etc. © 2021, Chemical Industry Press Co., Ltd. All right reserved.
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页码：3421 / 3433
页数：12
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