Regio- and Enantioselective Nickel-Catalyzed Ipso- and Remote Hydroamination Utilizing Organic Azides as Amino Sources for the Synthesis of Primary Amines

被引：8

作者：

Wang, Shi-Chao ^{[1
]}

Liu, Lin ^{[2
]}

Duan, Mei ^{[1
]}

Xie, Weijia ^{[1
]}

Han, Jiabin ^{[1
]}

Xue, Yuhang ^{[1
]}

Wang, You ^{[1
]}

Wang, Xiaotai ^{[2
]}

Zhu, Shaolin ^{[1
,3
,4
]}

机构：

[1] Nanjing Univ, Chem & Biomed Innovat Ctr ChemB, Sch Chem & Chem Engn, State Key Lab Coordinat Chem,Jiangsu Key Lab Adv O, Nanjing 210093, Peoples R China

[2] Xian Jiaotong Liverpool Univ, Dept Chem, Suzhou 215123, Peoples R China

[3] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China

[4] Shanghai Jiao Tong Univ, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2024年 / 146卷 / 44期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

ANTI-MARKOVNIKOV HYDROAMINATION; ALKYL-ARYL KETONES; UNACTIVATED ALKENES; REDUCTIVE AMINATION; INTERMOLECULAR HYDROAMINATION; ASYMMETRIC-SYNTHESIS; ACCESS; HYDROAMIDATION; MILD; FUNCTIONALIZATION;

D O I：

10.1021/jacs.4c12324

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Primary amines serve as key synthetic precursors to most other N-containing compounds, which are important in organic and medicinal chemistry. Herein, we present a NiH-catalyzed mild ipso- and remote hydroamination technique that utilizes organic azides as deprotectable primary amine sources. This strategy offers a highly flexible platform for the efficient construction of alpha-chiral branched primary amines, as well as linear primary amines.

引用

页码：30626 / 30636

页数：11

共 117 条

[1] Highly Regio- and Enantioselective Hydrosilylation of gem-Difluoroalkenes by Nickel Catalysis [J].