Discovery of bioactive peptides as therapeutic agents for skin wound repair

被引:13
作者
Fadilah, Nur Izzah Md [1 ,2 ]
Shahabudin, Nurul Aqilah [1 ]
Razif, Raniya Adiba Mohd [1 ]
Sanyal, Arka [3 ]
Ghosh, Anushikha [3 ]
Baharin, Khairul Idzwan [4 ]
Ahmad, Haslina [5 ,6 ]
Maarof, Manira [1 ,2 ]
Motta, Antonella [7 ]
Fauzi, Mh Busra [1 ,2 ]
机构
[1] Univ Kebangsaan Malaysia, Fac Med, Dept Tissue Engn & Regenerat Med, Kuala Lumpur, Malaysia
[2] Univ Kebangsaan Malaysia, Adv Bioact Mat Cells UKM Res Grp, Bangi, Selangor, Malaysia
[3] KIIT Univ, Dept Biotechnol, Bhubaneswar, India
[4] Wisma Cell Tissue WCT, Seri Kembangan, Selangor, Malaysia
[5] Univ Putra Malaysia, Integrated Chem Biophys Res, Upm Serdang, Selangor, Malaysia
[6] Univ Putra Malaysia, Fac Sci, Dept Chem, Upm Serdang, Selangor, Malaysia
[7] Univ Trento, Dept Ind Engn, Trento, Italy
关键词
Peptide; therapeutic agent; biological effect; skin; wound healing; tissue repair; HEALING-PROMOTING PEPTIDE; FIBROBLAST-GROWTH-FACTOR; HOST-DEFENSE PEPTIDES; ANTIMICROBIAL PEPTIDES; IN-VITRO; KERATINOCYTE MIGRATION; EPITHELIAL-CELLS; TGF-ALPHA; PROTEIN; MECHANISMS;
D O I
10.1177/20417314241280359
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Short sequences of amino acids called peptides have a wide range of biological functions and the potential to treat a number of diseases. Bioactive peptides can be derived from different sources, including marine organisms, and synthetic design, making them versatile candidates for production of therapeutic agents. Their therapeutic effects span across areas such as antimicrobial activity, cells proliferation and migration, synthesis of collagen, and more. This current review explores the fascinating realm of bioactive peptides as promising therapeutic agents for skin wound healing. This review focuses on the multifaceted biological effects of specific peptides, shedding light on their potential to revolutionize the field of dermatology and regenerative medicine. It delves into how these peptides stimulate collagen synthesis, inhibit inflammation, and accelerate tissue regeneration, ultimately contributing to the effective repair of skin wounds. The findings underscore the significant role several types of bioactive peptides can play in enhancing wound healing processes and offer promising insights for improving the quality of life for individuals with skin injuries and dermatological conditions. The versatility of peptides allows for the development of tailored treatments catering to specific wound types and patient needs. As continuing to delve deeper into the realm of bioactive peptides, there is immense potential for further exploration and innovation. Future endeavors may involve the optimization of peptide formulations, elucidation of underlying molecular and cellular mechanisms.
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页数:31
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