The scientific biography of corresponding member of the Russian Academy of Sciences L.N. Korolev is shortly described. He made the fundamental works on solving the encoding information-logical problems, development of the methods of automated programming and symbol transformations. He was a leader of a group of programmers created the first domestic operational control system. At the present time, he is a head of investigations on creation of the instrumental analysis system of dynamic processes on the basis of non-traditional approaches with using the technologies of neural networks and genetic algorithms.