Preparation of temperature-sensitive chromatographic materials via reversible addition fragmentation chain transfer polymerization

被引：0

作者：

Dong, Lin-Lin ^{[1
]}

Liang, Yan-Li ^{[1
]}

Deng, Yu-Lin ^{[1
]}

Dai, Rong-Ji ^{[1
]}

机构：

[1] School of Life Science, Beijing Institute of Technology, Beijing

来源：

Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology | 2015年 / 35卷

关键词：

N-isopropylacrylamide; Reversible addition fragmentation chain transfer(RAFT); Temperature-sensitive chromatography;

D O I：

10.15918/j.tbit1001-0645.2015.supplement1.030

中图分类号：

学科分类号：

摘要：

This paper prepared temperature-sensitive chromatographic materials via reversible addition fragmentation chain transfer polymerization (RAFT), and FT-IR, XPS, TG and element analysis characterizations indicated temperature-sensitive polymer grafted successfully onto silica. The introduction of S-benzyl dithiobenzoate that acted as chain transfer agent in RAFT formed an active site, which triggered polymerization of N-isopropylacrylamide on the surface of silica. The mole ratio of chain transfer agent and initiator was controlled to regulate the grafting ratio. TG analysis demonstrated the grafting ratio increased with a higher amount of initiator. The increasing grafting ratio improved thermosensitivity of HPLC performance of modified silica and separation of four steroids at 10, 30 and 50 ℃. Experimental results indicated RAFT successfully prepared temperature-sensitive chromatographic materials. ©, 2015, Beijing Institute of Technology. All right reserved.

引用

页码：137 / 141

页数：4

共 5 条

[1]

Xu Y.X., Li H.T., Zhang K., Et al., Synthesis of thermoresponsive polystyrene-based comb-type grafted poly(N-isopropylacrylamide), Science in China Series B: Chemistry, 50, 5, pp. 643-647, (2007)

[2]

Kanazawa H., Yamamoto K., Matsushima Y., Et al., Temperature-responsive chromatography using poly(N-isopropylacrylamide)-modified silica, Analyical Chemistry, 68, 1, pp. 100-105, (1996)

[3]

Thomas D.B., Anthony J.C., Mgrick L.J., Et al., Kinetics and molecular weight control of the polymerization of acrylamide via RAFT, Macromolecules, 37, 24, pp. 8941-8950, (2004)

[4]

Tang J., Hua D.B., Cheng J.X., Et al., Synthesis and properties of temperature-responsive chitosan by controlled free radical polymerization with chitosan-RAFT agent, International Journal of Biological Macromolecules, 43, 4, pp. 383-389, (2008)

[5]

Priyadarsi D., Li M., Sudershan R.G., Et al., Temperature-regulated activity of responsive polymer-protein conjugates prepared by grafting-from via RAFT polymerization, Journal of The American Chemical Society, 130, 34, pp. 11288-11289, (2008)

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