The role of extracellular vesicles in the treatment of tendinopathy by regulating the pathological immune microenvironment

被引：2
作者：
Liu, Hui-Min [1 ,2 ]
Zhu, Min [1 ,2 ]
Ding, Wei [1 ,2 ]
Ning, Liang-Ju [1 ,2 ]
Qin, Ting-Wu [1 ,2 ]
机构：
[1] Sichuan Univ, West China Hosp, Dept Orthoped Surg, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Hosp, Orthoped Res Inst, Stem Cell & Tissue Engn Res Ctr,State Key Lab Biot, Chengdu 610041, Peoples R China
来源：
CHEMICAL ENGINEERING JOURNAL | 2024年 / 499卷
基金：
中国国家自然科学基金;
关键词：
Extracellular vesicles; Tendinopathy; Immune microenvironment; Molecular mechanism; TENDON STEM-CELLS; ROTATOR CUFF TENDINOPATHY; HUMAN UMBILICAL-CORD; IN-VITRO; ACHILLES-TENDON; OXIDATIVE STRESS; REDOX REGULATION; BONE-MARROW; EXOSOMES; MATRIX;
D O I：
10.1016/j.cej.2024.156489
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Tendinopathy, a common degenerative condition among athletes and middle-aged individuals, leads to pain and functional limitations. Traditional treatments focus on symptom relief but do not address the underlying tendon pathology. New evidence points to immune microenvironment dysregulation as a key factor in tendinopathy development, often due to mechanical overload. Extracellular vesicles (EVs), nanosized particles containing active molecules, show promise in enhancing tendon healing by modulating the pathological microenvironment. This review explores the molecular mechanisms of the immune microenvironment in tendinopathy, highlights recent research on EVs in tendinopathy treatment, and discusses future research directions.
引用
收藏
页数：18
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