Aqueous plasma pharmacy: Preparation methods, chemistry, and therapeutic applications

被引：23
作者：
Joslin J.M. [1 ]
McCall J.R. [1 ]
Bzdek J.P. [1 ]
Johnson D.C. [1 ]
Hybertson B.M. [1 ,2 ]
机构：
[1] Symbios Technologies, Inc., Colorado State University Research Innovation Center, 3185 Rampart Road, Bldg. A, Fort Collins, 80523, CO
[2] Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, 80045, CO
来源：
Plasma Medicine | 2016年 / 6卷 / 02期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
Aqueous plasma pharmacy; Plasma medicine; Plasma pharmacy; Plasma-activated medium; Plasma-activated solution; Plasma-stimulated medium;
D O I：
10.1615/PlasmaMed.2016018618
中图分类号：
学科分类号：
摘要：
Plasma pharmacy is a subset of the broader field of plasma medicine. Although not strictly defined, the term aqueous plasma pharmacy (APP) is used to refer to the generation and distribution of reactive plasma-generated species in an aqueous solution followed by subsequent administration for therapeutic benefits. APP attempts to harness the therapeutic effects of plasma-generated oxidant species within aqueous solution in various applications, such as disinfectant solutions, cell proliferation related to wound healing, and cancer treatment. The subsequent use of plasma-generated solutions in the APP approach facilitates the delivery of reactive plasma species to internal locations within the body. Although significant efforts in the field of plasma medicine have concentrated on employing direct plasma plume exposure to cells or tissues, here we focus specifically on plasma discharge in aqueous solution to render the solution biologically active for subsequent application. Methods of plasma discharge in solution are reviewed, along with aqueous plasma chemistry and the applications for APP. The future of the field also is discussed regarding necessary research efforts that will enable commercialization for clinical deployment. © 2016 by Begell House, Inc.
引用
收藏
页码：135 / 177
页数：42
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