Shear stress-induced NO production model of vascular endothelial cell

被引：0
作者：
Ohashi Y. [1 ]
Yamazaki Y. [2 ]
Kamiyama Y. [1 ]
机构：
[1] Graduate School of Information Science and Technology, Aichi Prefectural University, 1152-3, Ibaragabasama, Nagakute, Aichi
[2] Priority Research Project, Aichi Science and Technology Foundation, Aichi Center for Industry and Science Technology, 1267-1, Akiai, Yakusa, Toyota, Aichi
来源：
IEEJ Transactions on Electronics, Information and Systems | 2016年 / 136卷 / 02期
关键词：
Arteriosclerosis; Electrophysiological Model; Endothelial Cells; Linear Characteristics; Nitric Oxide;
D O I：
10.1541/ieejeiss.136.116
中图分类号：
学科分类号：
摘要：
Endothelial dysfunction is known to be an early sign of arteriosclerosis. The shear stress-induced endothelial nitric oxide (NO) production is an important function of vascular system. In order to analyze this function, many in vitro experiments have been conducted and computer simulations with the mathematical models are utilized to analyze the experimental data. However, it is difficult to understand the whole function because each model simulates only a particular behavior. In this paper, we developed a multi-scale model that consists of mechanical and physiological models. This model simulates the shear stress-induced intracellular ion movements and NO synthesis. The proposed model is also able to simulate the NO production under eNOS inhibitor L-NAME. We performed the numerical experiments and demonstrated that the proposed model is capable of reproducing the experimental data of NO production. These results also suggest that the model can be used to develop a useful diagnostic application such as the estimation of in vivo NO concentration. © 2016 The Institute of Electrical Engineers of Japan.
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页码：116 / 122
页数：6
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