In vitro genotoxicity of extracellular extract from Nostoc piscinale

被引：2
|
作者：
Gharaei-Fathabad, Eshrat [1 ]
Yazdi, Mojtaba Tabatabaei [2 ]
Ostad, Seyed-Nasser [3 ]
Faramarzi, Mohammad Ali [2 ]
机构：
[1] Faculty of Pharmacy, Department of Pharmacognosy and Biotechnology, Mazandaran University of Medical Sciences, Sari 48175/861, Iran
[2] Biotechnology Research Center, Department of Pharmaceutical Biotechnology, University of Tehran, Tehran, 14174, Iran
[3] Medicinal Plant Research Center, Department of Toxicology and Pharmacology, University of Tehran, Tehran, 141155, Iran
来源：
Toxicological and Environmental Chemistry | 2008年 / 90卷 / 04期
关键词：
D O I：
10.1080/02772240701740304
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The extracellular extract obtained from 3 weeks incubation of the soil isolate cyanobacterium strain Nostoc piscinale GT-319 in BG-11 broth medium showed cytotoxic activity against Chinese Hamster Ovary (CHO) cells. Based on comet assay, a concentration of 333 μg mL-1 (IC50) produced DNA breakages in CHO cells. The concentration of 481 mg kg-1 (LD50) produced acute toxicity in mice at 48 h. © 2008 Taylor & Francis.
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收藏
页码：795 / 799
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