In order to study the behavior of sand under blast loading, the explosive tests were carried out in the explosion containment vessel (ECV) filled with sand. The test process was simulated by the finite element method software ANSYS/LS-DYNA. The dynamic response of the vessel was analyzed by 3D arbitrary Lagrangian-Euler fluid-structure interaction coupling method and 2D Lagrangian adaptivity method. The simulated hoop strain on the ECV's outer surface right opposite to the charge centre coincides with the experiment data at large charge mass better. Besides, the overpressure acting on the inner wall and the dimension of the cavity in sand were obtained from the numerical simulation also.