A device for localized measurement of small particles with electrode-integrated small pores

被引:0
作者
Takeshiro Y. [1 ]
Usami N. [1 ]
Okamoto Y. [1 ]
Takada T. [2 ]
Higo A. [3 ]
Ikeno R. [3 ]
Washizu N. [2 ]
Asada K. [3 ]
Mita Y. [1 ]
机构
[1] Department of Electrical Engineering and Information Systems, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo
[2] Advantest Corporation, 1-6-2, Marunouchi, Chiyoda-ku, Tokyo
[3] VLSI Design and Education Center, University of Tokyo, 2-11-16, Yayoi, Bunkyo-ku, Tokyo
关键词
Anisotropic etching; Coulter counter; DRIE; Small pore;
D O I
10.1541/ieejsmas.139.271
中图分类号
学科分类号
摘要
In this article, we propose a device with multiple small pores, which are locally integrated with individual electrodes. The application is particle measurement using Coulter’s method, using the integrated local electrode on each pore. Coulter’s particle counter can achieve high resolution measurement; however, the method had sensitivity and throughput tradeoff problem in reducing measurable particle size. The system can locally observe current around the pore and thereby parallel measurement becomes possible while keeping high sensitivity. The fabricated pore size were 400 nm, 1.0 µm, and 1.5 µm. Spontaneous water flow was achieved with 1.5 µm device, and current dip attributable to Coulter’s principle was observed. © 2019 The Institute of Electrical Engineers of Japan.
引用
收藏
页码:271 / 276
页数:5
相关论文
共 11 条
[1]  
Roberts G.S., Yu S., Zeng Q., Chan L.C.L., Anderson W., Colby A.H., Grinstaff M.W., Reid S., Vogel R., Tunable pores for measuring concentrations of synthetic and biological nanoparticle dispersions, Biosensors and Bioelectronics, 31, 1, pp. 17-25, (2012)
[2]  
Coulter W.H., (1953)
[3]  
Yang L., Broom M.F., Tucker I.G., Characterization of a nanoparticulate drug delivery system using scanning ion occlusion sensing, Pharmaceutical Research, 29, 9, pp. 2578-2586, (2012)
[4]  
Anderson W., Kozak D., Coleman V.A., Jamting A.K., Trau M., A comparative study of submicron particle sizing platforms: Accuracy, precision and resolution analysis of polydisperse particle size distributions, Journal of Colloid and Interface Science, 405, pp. 322-330, (2013)
[5]  
Agrawal K.V., Drahushuk L.W., Strano M.S., Observation and analysis of the Coulter effect through carbon nanotube and graphene nanopores, Phil. Trans. R. Soc. A, 374, (2016)
[6]  
Han A., Schurmann G., Mondin G., Bitterli R.A., Hegelbach N.G., De Rooij N.F., Staufera U., Sensing protein molecules using nanofabricated pores, Appl. Phys. Lett., 88, (2006)
[7]  
Liu S., Yuzvinsky T.D., Schmidt H., Effect of fabrication-dependent shape and composition of solid-state nanopores on single nanoparticle detection, ACS Nano, 7, 6, pp. 5621-5627, (2013)
[8]  
Vogel R., Willmott G., Kozak D., Roberts G.S., Anderson W., Groenewegen L., Glossop B., Barnett A., Turner A., Trau M., Quantitative sizing of nano/microparticles with a tunable elastomeric pore sensor, Analytical Chemistry, 83, 9, pp. 3499-3506, (2011)
[9]  
Jagtiani A.V., Ashish V., Hu J., Carletta J., Zhe J., A high throughput multiplexed micro coulter counter using amplitude modulation, UGIM Proceedings, pp. 173-176, (2008)
[10]  
Heins E.A., Siwy Z.S., Baker L.A., Martin C.R., Detecting single porphyrin molecules in a conically shaped synthetic nanopore, Nano Letters, 5, 9, pp. 1824-1829, (2005)