In through-the-wall radar imaging (TWRI), wall returns are often stronger than target returns, which make the targets behind walls invisible in the radar image. Spatial -ltering that relies on the removal of the spatial zero-frequency components is a useful way for wall-clutter mitigation. Unfortunately, it applies to through-the-wall radar (TWR) with synthetic aperture array only. In this paper, a method based on spatial signature is proposed to suppress the wall-clutter in multi-input and multi-output (MIMO) TWRI. Firstly, the traditional spatial -ltering method is discussed, as well as the reasons for the inapplicability for MIMO TWR. Secondly, the wall and target spatial signatures based on MIMO array are analyzed, respectively. The results indicate that the former has stability and symmetry, whereas the latter not. Thirdly, according to the above di®erences, a new method, symmetry subtraction, is applied to describe the wall-clutter suppression procedure. Finally, simulation results demonstrate that the proposed method is e±cient in mitigating the wall returns and highlighting the targets.