Effect of concomitant 18O in 13C-urea on the urea breath test

被引：0

作者：

Maruyama, Wataru ^{[1
,4
]}

Mori, Masami ^{[1
]}

Sato, Rie ^{[1
]}

Kajiwara, Masahiro ^{[2
]}

Kimura, Ken ^{[3
]}

机构：

[1] Fine Chemicals Department, Shoko Co., Ltd., 8-3 Nishi-Shimbashi, 3-Chome, Minato-ku, Tokyo 105, Japan

[2] Department of Medicinal Chemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-00004, Japan

[3] Department of Gastroenterology, Jichi Medical School, Yakushiji, Tochigi 329-04, Japan

[4] Fine Chemicals Department, Shoko Co., Ltd., 8-3 Nishi-Shimbashi 3-Chome, Minato-KJ Tokyo 105-8432, Japan

来源：

Journal of Labelled Compounds and Radiopharmaceuticals | 2000年 / 43卷 / 11期

关键词：

13C - 18O -urea - 18O-isotopic exchange reaction - Breath tests - Helicobacter pylori infections - Isotope effect - Isotopic exchange reactions - Mass spectra - Natural abundance - Urea breath test;

D O I：

10.1002/1099-1344(20001015)43:113.0.CO;2-M

中图分类号：

学科分类号：

摘要：

Helicobacter pylori infection in stomach has been extensively assessed by the 13C-urea breath test(UBT) with infra-red or mass spectrometer. However, analyses of commercially available 13C-urea for UBT showed about 10 atom% of 18O abundance. It is therofore very important to investigate the 18O-isotope effect on UBT. Using a mass spectrometer, breath samples of UBT were analyzed to investigate the change of mass spectra by the isotopic exchange reaction between 18O of carbon dioxide and 16O of water. As the result, the 18O content 13C, 18-carbon dioxide exhaled in UBT reached its natural abundance level immediately after the administration of 13C, 18O-urea. It was concluded that the 18O content of 13C, 18O-urea has no effect on UBT using either infra-red or mass spectroscopy. (C) 2000 John Wiley and Sons, Ltd.

引用

页码：1113 / 1118