Apolipoprotein E polymorphism in tuberculosis patients

被引：1

作者：

Farivar, Taghi Naserpour ^{[1
]}

Moud, Batool Sharifi ^{[2
]}

Sargazi, Mansur ^{[3
]}

Moeenrezakhanlou, Alireza ^{[4
]}

机构：

[1] Department of Microbiology, Research Institute of Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan

[2] Department of Infectious Disease, School of Medicine, Zahedan University of Medical Sciences, Zahedan

[3] Department of Clinical Biochemistry and Metabolic Medicine, Royal Liverpool University Hospital, Liverpool

[4] Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC

来源：

Journal of Applied Sciences | 2008年 / 8卷 / 04期

关键词：

Apolipoprotein E polymorphism; Tuberculosis;

D O I：

10.3923/jas.2008.719.722

中图分类号：

学科分类号：

摘要：

In this study, we aimed to determine the significance of association between Tuberculosis and apolipoprotein E polymorphism. The apolipoprotein E genotypes were assayed in 250 tuberculosis patients by polymerase chain reaction followed by enzymatic digestion with Hha I. The results were compared with the results of the same experiments on 250 sex and age matched control peoples. Present results showed that in studied populations, prevalence of E4 genotype was lower in controls than in patients (8 v. 13.2%; OR = 1.75, p<0.05) and prevalence of E3 genotype was high in controls than in patients (86 v.51%, OR = 0.17, p<0.05). Statistically significant difference was found between patients and controls with respect to ε2 allele frequencies, while ε2 allele frequency was found to be much less prevalent in controls (6%) than in patients (35.8%; OR = 8.72, p<0.05). Also, our study revealed that there is an association between apolipoprotein E genotypes and amplitude to tuberculosis in studied populations. However, large population-based studies are needed to understand the exact role played by the locus in causing the condition. © 2008 Asian Network for Scientific Information.

引用

页码：719 / 722

页数：3

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