Neuropil fiber reduction in brain tumors observed by atomic force microscopy

被引：0

作者：

Schilcher K. ^{[1
]}

Silye R. ^{[2
]}

Huber H.-P. ^{[1
]}

机构：

[1] School of Applied Health and Social Sciences, Upper Austria University of Applied Sciences, 4020 Linz

[2] Department of Pathology and Neuropatholgy, Nerve Clinic Linz, 4020 Linz

来源：

Journal of Advanced Microscopy Research | 2010年 / 5卷 / 02期

关键词：

Astrocytoma; Atomic Force Microscopy; Clinical Diagnostics; Neuropathology; Neuropil;

D O I：

10.1166/jamr.2010.1028

中图分类号：

学科分类号：

摘要：

Atomic force microscopy plays a fundamental role in the investigation of biological processes at nanometer level. In this study we used atomic force microscopy on routine uncovered histological brain samples to gain a detailed insight into the complex brain's architecture at a high magnification and a high resolution. We have applied this method to post mortem and neurosurgical brain specimens and the images revealed morphological details concerning the organisation of the network-like neuropil and the reduction in its fibres in neoplastically transformed astrocytic brain tumors. The data suggest the use of the neuropil fiber reduction as a diagnostic marker to assess the degree of astrocytomas. The results clearly demonstrate that atomic force microscopy could serve as a powerful tool in clinical diagnostics. Copyright © 2010 American Scientific Publishers.

引用

页码：86 / 90

页数：4

共 28 条

[1]

Horber J.K.H., Miles M.J., Science, 302, (2003)

[2]

Buzhynskyy N., Girmens J.F., Faigle W., Scheuring S., J. Mol. Biol., 374, (2007)

[3]

Morris V.J., Kirby A.R., Gunning A.P., Atomic Force Microscopy For Biologist, (2008)

[4]

Henderson E., Haydon P.G., Sakaguchi D.S., Science, 257, (1992)

[5]

Henderson E., Sakaguchi D.S., NeuroImage, 17, (1993)

[6]

Parpura V., Haydon P.G., Henderson E., J. Cell Sci., 104, (1993)

[7]

Bonfiglio A., Parodi M.T., Tonini G.P., Exp. Cell Res., 216, (1995)

[8]

Yamane Y., Shiga H., Asou H., Haga H., Kawabata K., Abe K., Ito E., Arch. Histol. Cytol., 62, (1999)

[9]

Teodori L., Albertini M.C., Uguccioni F., Falcieri E., Rocchi M.B.L., Battistelli M., Coluzza C., Piantanida G., Bergamaschi A., Magrini A., Mucciato R., Accorsi A., Cytometry, 69 A, 75, (2005)

[10]

Bystrenova E., Tonazzini I., Lazar A., Stoliar P., Dionigi C., Cacace M., Biscarini F., Huth M., Nickel B., Jelitai M., Madarasz E., Adv. Funct. Mater., 18, (2008)

← 1 2 3 →