Molecular design of synthetic receptors with dynamic, imprinting, and allosteric functions

被引：0

作者：

机构：

[1] [1,2,Shinkai, Seiji

[2] Takeuchi, Masayuki

来源：

Shinkai, S. (seijitcm@mbox.nc.kyushu-u.ac.jp) | 1600年 / Chemical Society of Japan卷 / 78期

关键词：

Alcohols - Amino acids - Biological membranes - Boron - Chemical bonds - Gels - Micelles;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Sugar recognition in an aqueous system has been achieved using a boronic acid-diol interaction. Combination with an intramolecular amino group has enabled us to read out the binding process as a change in the fluorescence intensity. This novel sugar-sensing method has been combined with a concept of molecular machinery, providing a new guest-binding mode with allosteric functions. When this method is combined with a concept of molecular imprinting, it becomes possible to design sugar-selective receptors created by a combinatorial method. The sugar recognition event is useful as a trigger to control molecular assemblies such as micelles, membranes, vesicles, and gels.

引用