Can microfluidics address biomanufacturing challenges in drug/gene/cell therapies?

被引：29

作者：

Chan, Hon Fai ^{[1
]}

Ma, Siying ^{[1
]}

Leong, Kam W. ^{[1
]}

机构：

[1] Columbia Univ, Dept Biomed Engn, Dept Syst Biol, New York, NY 10032 USA

来源：

REGENERATIVE BIOMATERIALS | 2016年 / 3卷 / 02期

关键词：

microfluidics; biomanufacturing; nanoparticle; microencapsulation; microfiber; PLGA NANOPARTICLES; DRUG-DELIVERY; GENE-THERAPY; CELL MICROENCAPSULATION; CLINICAL TRANSLATION; FLOW LITHOGRAPHY; MASS-PRODUCTION; MONODISPERSE; ENCAPSULATION; SIZE;

D O I：

10.1093/rb/rbw009

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Translation of any inventions into products requires manufacturing. Development of drug/gene/cell delivery systems will eventually face manufacturing challenges, which require the establishment of standardized processes to produce biologically-relevant products of high quality without incurring prohibitive cost. Microfluidicu technologies present many advantages to improve the quality of drug/gene/cell delivery systems. They also offer the benefits of automation. What remains unclear is whether they can meet the scale-up requirement. In this perspective, we discuss the advantages of microfluidic-assisted synthesis of nanoscale drug/gene delivery systems, formation of microscale drug/cell-encapsulated particles, generation of genetically engineered cells and fabrication of macroscale drug/cell-loaded micro-/nano-fibers. We also highlight the scale-up challenges one would face in adopting microfluidic technologies for the manufacturing of these therapeutic delivery systems.

引用

页码：87 / 98

页数：12

共 110 条

[1]

Abate AR, 2011, LAB CHIP, V11, P253, DOI [10.1039/c0lc00236d, 10.1039/c01c00236d]

[2] Encapsulation of hydrophilic and lipophilic drugs in PLGA nanoparticles by the nanoprecipitation method [J].

Barichello, JM ;

Morishita, M ;

Takayama, K ;

Nagai, T .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1999, 25 (04) :471-476

[3] Dynamics of microfluidic droplets [J].

Baroud, Charles N. ;

Gallaire, Francois ;

Dangla, Remi .

LAB ON A CHIP, 2010, 10 (16) :2032-2045

[4] Precise control of PLG microsphere size provides enhanced control of drug release rate [J].

Berkland, C ;

King, M ;

Cox, A ;

Kim, K ;

Pack, DW .

JOURNAL OF CONTROLLED RELEASE, 2002, 82 (01) :137-147

[5] Nanoprecipitation versus emulsion-based techniques for the encapsulation of proteins into biodegradable nanoparticles and process-related stability issues [J].

Bilati, U ;

Allémann, E ;

Doelker, E .

AAPS PHARMSCITECH, 2005, 6 (04)

[6] A stopped-flow kinetic study of the assembly of nonviral gene delivery complexes [J].

Braun, CS ;

Fisher, MT ;

Tomalia, DA ;

Koe, GS ;

Koe, JG ;

Middaugh, CR .

BIOPHYSICAL JOURNAL, 2005, 88 (06) :4146-4158

[7]

Cabral H, 2011, NAT NANOTECHNOL, V6, P815, DOI [10.1038/nnano.2011.166, 10.1038/NNANO.2011.166]

[8] Mammalian Cell Viability in Electrospun Composite Nanofiber Structures [J].

Canbolat, Mehmet Fatih ;

Tang, Christina ;

Bernacki, Susan H. ;

Pourdeyhimi, Behnam ;

Khan, Saad .

MACROMOLECULAR BIOSCIENCE, 2011, 11 (10) :1346-1356

[9] Micro/Nanometer-Scale Fiber with Highly Ordered Structures by Mimicking the Spinning Process of Silkworm [J].

Chae, Su-Kyoung ;

Kang, Edward ;

Khademhosseini, Ali ;

Lee, Sang-Hoon .

ADVANCED MATERIALS, 2013, 25 (22) :3071-3078

[10] A Robust Strategy for Negative Selection of Cre-LoxP Recombination-Based Excision of Transgenes in Induced Pluripotent Stem Cells [J].

Chakraborty, Syandan ;

Christoforou, Nicolas ;

Fattahi, Ali ;

Herzog, Roland W. ;

Leong, Kam W. .

PLOS ONE, 2013, 8 (05)

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