Effect of Glycated SOD on Hypoglycemic Action in Alloxan-induced Diabetic Rats

被引：0
|
作者：
Zhao D. [1 ]
Cai L. [1 ]
Fu T. [1 ]
Zhang H. [1 ]
Liu S. [1 ,3 ]
Rao P. [2 ]
机构：
[1] Institute of Biotechnology, Fuzhou University, Fuzhou
[2] Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences-Zhejiang Gong Shang University Joint Centre for Food and Nutrition Research, Hangzhou
[3] Key Laboratory of Opto Electronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou
来源：
Liu, Shutao (stliu@fzu.edu.cn) | 2018年 / Chinese Institute of Food Science and Technology卷 / 18期
关键词：
Diabetes; Maillard reaction; SOD;
D O I：
10.16429/j.1009-7848.2018.06.003
中图分类号：
学科分类号：
摘要：
In order to explore the impact of auxiliary hypoglycemic of superoxide dismutase (SOD) by Maillard reaction, based on bovine blood SOD as raw material, added glucose for non-enzymatic glycation reaction, the glycated SOD (SOD-G) and single bovine blood SOD were used to treat alloxan-induced diabetic rats, to compare the effect of weight, blood glucose, oral glucose tolerance, the SOD levels of tissue organs (Heart, liver, kidney, pancreas and skeletal muscle) and the level of plasma insulin (INS), amp activated protein kinase (AMPK) and malondialdehyde (MDA) of diabetic rats given SOD and an equal dose of SOD-G, as well as different doses of SOD-G. The test results show that SOD-G and SOD have a significant effect on reduction of blood glucose in alloxan-induced type I diabetic rats, but each has its advantages. There are no differences in body weight control. SOD-G hypoglycemic effect is significantly better than SOD (P<0.05), while in the OGTT test, the effect of SOD on glucose tolerance damage is significantly better than SOD-G (P<0.05). In tissue SOD level test, both of them increase the content of SOD in the pancreas, and have no significant effect on the SOD content in skeletal muscle and heart, and SOD level of liver and kidney in SOD-G group is significantly lower than that in SOD group, There are no significant difference in INS, AMPK, and MDA levels.These results indicate that superoxide dismutase, in the wake of the Maillard reaction modification, still has obvious auxiliary hypoglycemic effect, and the overall effect of SOD-G is better than SOD. But maybe due to the Maillard reaction modification its structure changes, and SOD-G and SOD in vivo absorption way changes, there are some differences in the final treatment effect. © 2018, Editorial Office of Journal of CIFST. All right reserved.
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页码：19 / 26
页数：7
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