An efficient and environmental friendly synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione in aqueous hydrotropic medium

被引：0

作者：

Dhane, Nilam S. ^{[1
]}

Sapkal, Aboli C. ^{[2
]}

Dhumal, Nilam P. ^{[2
]}

Gaikwad, Dhananjay N. ^{[2
]}

Kamble, Santosh B. ^{[2
]}

Gaikwad, Kishor, V ^{[1
]}

机构：

[1] Rajarshi Chhatrapati Shahu Coll, Kolhapur, India

[2] Karmaveer Bhaurao Patil Univ, Yashavantrao Chavan Inst Sci Satara, Lead Coll, Satara, India

来源：

JOURNAL OF CHEMICAL SCIENCES | 2024年 / 136卷 / 04期

关键词：

Green chemistry; multi-component reactions; catalyst free; aqueous hydrotropic medium; heterocycles; room temperature; 1H-pyrazolo[1,2-b]phthalazine-5,10-dione; GREEN SYNTHESIS; PHTHALAZINE-5,10-DIONE DERIVATIVES; MULTICOMPONENT SYNTHESIS; CATALYST; NANOPARTICLES;

D O I：

10.1007/s12039-024-02310-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This study reports a hydrotropic activity for synthesizing 1H-pyrazolo[1,2-b]phthalazine-5,10-dione through one pot four component aldehyde condensation, malononitrile, phthalic anhydride, and hydrazine hydrate. The simple and green hydrotropic synthetic approach offers numerous advantages such as non-toxic, inexpensive, mild reaction conditions, avoidance of harmful solvents, shorter reaction time, an excellent yield of products, simple workup, Chromatography-free, and eco-friendly. 1H-NMR confirmed all the synthesized compounds.

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页数：11

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