An efficient and environmental friendly synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione in aqueous hydrotropic medium

被引：0
作者：
Dhane, Nilam S. [1 ]
Sapkal, Aboli C. [2 ]
Dhumal, Nilam P. [2 ]
Gaikwad, Dhananjay N. [2 ]
Kamble, Santosh B. [2 ]
Gaikwad, Kishor, V [1 ]
机构：
[1] Rajarshi Chhatrapati Shahu Coll, Kolhapur, India
[2] Karmaveer Bhaurao Patil Univ, Yashavantrao Chavan Inst Sci Satara, Lead Coll, Satara, India
来源：
JOURNAL OF CHEMICAL SCIENCES | 2024年 / 136卷 / 04期
关键词：
Green chemistry; multi-component reactions; catalyst free; aqueous hydrotropic medium; heterocycles; room temperature; 1H-pyrazolo[1,2-b]phthalazine-5,10-dione; GREEN SYNTHESIS; PHTHALAZINE-5,10-DIONE DERIVATIVES; MULTICOMPONENT SYNTHESIS; CATALYST; NANOPARTICLES;
D O I：
10.1007/s12039-024-02310-5
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This study reports a hydrotropic activity for synthesizing 1H-pyrazolo[1,2-b]phthalazine-5,10-dione through one pot four component aldehyde condensation, malononitrile, phthalic anhydride, and hydrazine hydrate. The simple and green hydrotropic synthetic approach offers numerous advantages such as non-toxic, inexpensive, mild reaction conditions, avoidance of harmful solvents, shorter reaction time, an excellent yield of products, simple workup, Chromatography-free, and eco-friendly. 1H-NMR confirmed all the synthesized compounds.
引用
收藏
页数：11
相关论文
共 62 条
[1]   Gel entrapped ZnO nanorods: An efficient and sustainable catalyst for the Claisen-Schmidt condensation reaction in aqueous hydrotropic media [J].
Attar, Suraj R. ;
Sapkal, Aboli C. ;
Bagade, Chaitali S. ;
Mujawar, Sarfraj H. ;
Kamble, Santosh B. .
MOLECULAR CATALYSIS, 2023, 542
[2]   Enhanced catalytic activity of bio-fabricated ZnO NPs prepared by ultrasound-assisted route for the synthesis of tetraketone and benzylidenemalonitrile in hydrotropic aqueous medium [J].
Attar, Suraj R. ;
Shinde, Bipin ;
Kamble, Santosh B. .
RESEARCH ON CHEMICAL INTERMEDIATES, 2020, 46 (10) :4723-4748
[3]  
Badiger K B, 2023, Polycycl. Aromat. Compd. 0, P1
[4]   Enhancement of aqueous solubility and extraction of lauric acid using hydrotropes and its interaction studies by COSMO-RS model [J].
Balachandran, S. ;
Gnana Prakash, D. ;
Anantharaj, R. ;
Danish John Paul, M. R. .
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, 2021, 42 (12) :1820-1829
[5]   One-drop organocatalyzed multicomponent synthesis of pyrazolo[1,2-b]phthalazine-diones and pyrazolophthalazinyl quinolines [J].
Barge, Madhuri ;
Rashinkar, Gajanan ;
Kanase, Dhanaji ;
Mohite, Suhas ;
Lohar, Trushant .
RESEARCH ON CHEMICAL INTERMEDIATES, 2022, 48 (12) :5045-5058
[6]   Hydrotrope: green and rapid approach for the catalyst-free synthesis of pyrazole derivatives [J].
Barge, Madhuri ;
Kamble, Santosh ;
Kumbhar, Arjun ;
Rashinkar, Gajanan ;
Salunkhe, Rajashri .
MONATSHEFTE FUR CHEMIE, 2013, 144 (08) :1213-1218
[7]   CuII Anchored onto the Magnetic Talc: A New Magnetic Nanostructured Catalyst for the One-Pot Gram-Scale Synthesis of 1H-Pyrazolo[1,2-b]phthalazine-5,10-dione Derivatives [J].
Chalaki, Samaneh B. ;
Akhlaghinia, Batool .
CHEMISTRYSELECT, 2020, 5 (35) :11010-11019
[8]   Microwave-assisted three-component synthesis of 7-aryl-2-alkylthio-4,7-dihydro-1,2,4-triazolo[1,5-a]-pyrimidine-6-carboxamides and their selective reduction [J].
Chebanov, VA ;
Muravyova, EA ;
Desenko, SM ;
Musatov, VI ;
Knyazeva, IV ;
Shishkina, SV ;
Shishkin, OV ;
Kappe, CO .
JOURNAL OF COMBINATORIAL CHEMISTRY, 2006, 8 (03) :427-434
[9]   Lipase-mediated multicomponent synthesis of 1H-Pyrazolo[1,2-b]phthalazine-5,10-dione derivatives in a binary solvent medium [J].
Dalal, Kiran S. ;
Tayade, Yogesh A. ;
Wagh, Yogesh B. ;
Dalal, Dipak S. ;
Chaudhari, Bhushan L. .
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 2022, 69 (05) :2017-2027
[10]   Synthesis of 1, 8-dioxodecahydroacridines via Hantzsch condensation using theophylline in an aqueous medium: an eco-friendly and bio-based approach [J].
Dhane, Nilam S. ;
Sapkal, Aboli C. ;
Attar, Suraj R. ;
Dhumal, Sanchita M. ;
Chougule, Ganesh K. ;
Pawar, Samadhan P. ;
Kamble, Santosh B. ;
Gaikwad, Kishor V. .
RESEARCH ON CHEMICAL INTERMEDIATES, 2024, 50 (03) :1147-1160
1234567