Assessment of stability of a spray dried extract from the medicinal plant Bidens pilosa L.

被引：12

作者：

Cortés-Rojas D.F. ^{[1
]}

Souza C.R.F. ^{[1
]}

Oliveira W.P. ^{[1
]}

机构：

[1] University of Sao Paulo, School of Pharmaceutical Sciences of Ribeirao Preto, Av. do Café s/n, Ribeirão Preto, 14040-903, SP

来源：

Journal of King Saud University - Engineering Sciences | 2016年 / 28卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

Dried extract; Microparticles; Phytopharmaceutical preparation; Stability;

D O I：

10.1016/j.jksues.2014.04.004

中图分类号：

学科分类号：

摘要：

Spray drying has been successfully employed for the encapsulation of herbal bioactive compounds resulting in stable phytopharmaceutical preparations. Bidens pilosa L. is a South American medicinal plant with proved antimalaric, hepatoprotector and antioxidant activities, generally linked to their secondary metabolites, flavonoids and polyacetylenes. In this work the physicochemical stability of an optimized spray dried composition from a B. pilosa extract was evaluated at three different stress storage conditions in open containers and in sealed sachets. High performance liquid chromatography was employed to monitor the concentration of three marker compounds over 12 months. Color variation of the stored samples was evaluated by using a color spectrophotometer. It was observed that the concentration of the monitored compounds of the plant decreases more drastically in samples stored in open containers. The two flavonoids monitored, rutin and hyperoside, showed lower degradation than the polyacetylene. The concentration of the markers did not change significantly at the lowest temperature. With regard to color, darker hues were observed at higher temperatures and storage times. This study showed that the storage conditions cause significant impact on stability of standardized spray dried B. pilosa extract. © 2014

引用

页码：141 / 146

页数：5

共 31 条

[1]

Ameri M., Maa Y.-F., Spray drying of biopharmaceuticals: stability and process considerations, Dry. Technol., 24, pp. 763-768, (2006)

[2]

Andrade-Neto V.F., Brandao M.G.L., Oliveira F.Q., Casali V.W.D., Njaine B., Zalis M.G., Oliveira L., Krettli A.U., Antimalarial activity of Bidens pilosa L. (Asteraceae) ethanol extracts from wild plants collected in various localities or plants cultivated in humus soil, Phytother. Res., 18, pp. 634-639, (2004)

[3]

Bakowska-Barczak A.M., Kolodziejczyk P.P., Black currant polyphenols: their storage stability and microencapsulation, Ind. Crops Prod., 34, pp. 1301-1309, (2011)

[4]

Bero J., Frederich M., Quetin-Leclercq J., Antimalarial compounds isolated from plants used in traditional medicine, J. Pharm. Pharmacol., 61, pp. 1401-1433, (2009)

[5]

Bhandari B.R., Howes T., Implication of glass transition for the drying and stability of dried foods, J. Food Eng., 40, pp. 71-79, (1999)

[6]

Bott R.F., Labuza T.P., Oliveira W.P., Stability testing of spray- and spouted bed–dried extracts of Passiflora alata, Dry. Technol., 28, pp. 1255-1265, (2010)

[7]

Braga G.K., Oliveira W.P., Manufacturing drug loaded chitosan microspheres by spray drying: development, characterization, and potential use in dentistry, Dry. Technol., 25, pp. 303-310, (2007)

[8]

Brandao M.G.L., Krettli A.U., Soares L.S.R., Nery C.G.C., Marinuzzy H.C., Antimalarial activity of extracts and fractions from Bidens pilosa and other Bidens species (Asteraceae) correlated with the presence of acetylene and flavonoid compounds, J. Ethnopharmacol., 57, pp. 131-138, (1997)

[9]

Cano-Chauca M., Stringheta P.C., Ramos A.M., Cal-Vidal J., Effect of the carriers on the microstructure of mango powder obtained by spray drying and its functional characterization, Innov. Food Sci. Emerg. Technol., 6, pp. 420-428, (2005)

[10]

Chiang Y.-M., Chuang D.-Y., Wang S.-Y., Kuo Y.-H., Tsai P.-W., Shyur L.-F., Metabolite profiling and chemopreventive bioactivity of plant extracts from Bidens pilosa, J. Ethnopharmacol., 95, pp. 409-419, (2004)

← 1 2 3 4 →