An information and theoretic analysis of the chicken basic helix-loop-helix transcription factors based on Shannon entropy

被引：0
作者：
机构：
[1] Department of Biology Sciences, Fuyang Normal College
[2] Department of Science and Technology, Fuyang Normal College, Fuyang
来源：
Liu, W. | 1600年 / Asian Network for Scientific Information卷 / 13期
关键词：
BHLH; Information theory; Protein domain; Shannon entropy; Transcription factor;
D O I：
10.3923/biotech.2014.99.105
中图分类号：
学科分类号：
摘要：
Statistical analysis of the chicken (Gallus gallus) genome can provide unique perspectives on avian development and evolution. The basic helix-loop-helix (bHLH) transcription factor family plays important roles in a wide range of developmental and evolutionary processes. It has been identified in many organisms such as human, mouse, rat, worms, flies, fungi and plants. Previously, we identified 104 bHLH protein sequences in the genome of chicken, Gallus gallus. Among these bHLH transcription factors, 11 were predicted Ab initio proteins and 1 was finished clone mRNA without full protein sequence. In the present study we carried out an information theoretic analysis of sequence variability and compositional characteristics of the remained 92 chicken representative bHLH domains with Shannon entropy values computed for amino acid sites. We inferred that there exists a high diversity within the chicken bHLH family. The present study provides much useful information for further studies using chicken as a model animal system. © 2014 Asian Network for Scientific Information.
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页码：99 / 105
页数：6
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