Effects of the blueberry polyphenols on the secretion of NO, iNOS, COX-2 in mice macrophages

被引：0
|
作者：
Han, Caijing [1 ,2 ]
Wang, Wenliang [1 ]
Chen, Xiangyan [1 ]
Cheng, Anwei [1 ]
Xie, Chunyang [2 ]
Gong, Zhiqing [1 ]
机构：
[1] Institute of Agro-Food Science and Technology, Shandong Academy of Agricultural Science, Jinan
[2] College of Food Science and Technology, Jilin Agricultural University, Changchun
来源：
Journal of Chinese Institute of Food Science and Technology | 2015年 / 15卷 / 02期
关键词：
Blueberry polyphenols; COX-2; INOS; Macrophages; NO;
D O I：
10.16429/j.1009-7848.2015.02.003
中图分类号：
学科分类号：
摘要：
The effects of EPP and NEPP from blueberries on the secretion of NO, iNOS, COX-2 in LPS-prestimulated RAW264.7 cells, were studied in the paper. The results showed that the secretion of NO, iNOS, COX-2 can be decreased by EPP and NEPP in the RAW264.7 cell, and the inhibitory effect was enhanced with the increasing of concentration. At the same concentration, the inhibitory effect of NEPP was better than that of EPP and the positive control (TP). It is suggested that EPP and NEPP from blueberries have significant anti-inflammatory effect by inhibitting the secretion of NO, iNOS and COX-2 in macrophages. ©, 2015, Chinese Institute of Food Science and Technology. All right reserved.
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页码：15 / 20
页数：5
相关论文
共 13 条
  • [1] Arranz S., Saura-Calixto F., Shaha S., Et al., High content of nonextractable polyphenols in fruits suggest that polyphenol content of plant foods have been underestimated, Journal of Agricultural Food and Chemistry, 57, pp. 7298-7303, (2009)
  • [2] Chen K., Maines M.D., Nitric oxide induces heme oxygenase-1 via mitogen-activated protein kinases ERK and p38, Cellular & Molecular Biology Letters, 46, 3, pp. 609-617, (2000)
  • [3] Nanji A.A., Jokelainen K., Tipoe G.L., Et al., Dietary saturated fatty acids reverse inflammatory and fibrotic changes in rat liver despite continued ethanol administration, Journal of Pharmacology and Experimental Therapeutics, 299, 2, pp. 638-644, (2001)
  • [4] Cheng A.W., Chen X.Y., Wang W.L., Et al., Contents of extractable and non-extractable polyphenols in the leaves of blueberry, Czech of Journal of Food Sciences, 31, pp. 275-282, (2013)
  • [5] Lau F.C., Joseph J.A., McDonald J.E., Et al., Attenuation of iNOS and COX2 by blueberry polyphenols is mediated through the suppression of NF-kB activation, Journal of Functional Foods, 1, 3, pp. 274-283, (2009)
  • [6] Kimura H., Weisz A., Kurashina Y., Et al., Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide, Blood, 95, 1, pp. 189-197, (2000)
  • [7] Cianchi F., Cortesini C., Fantappie O., Et al., Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancer, Clinical Cancer Research, 10, 8, pp. 2694-2704, (2004)
  • [8] Madhujith T., Shahidi F., Antioxidant potential of barley as affected by alkaline hydrolysis and release of insoluble-bound phenolics, Food Chemistry, 117, pp. 615-620, (2009)
  • [9] Kristl J., Slekovec M., Tojnko S., Et al., Extractable antioxidants and non-extractable phenolics in the total antioxidant activity of selected plum cultivars (Prunus domestica L.): Evolution during on-tree ripening, Food Chemistry, 125, pp. 29-34, (2011)
  • [10] Huie R.E., Padmaja S., Reaction of NO with O<sub>2</sub><sup>-</sup>, Free Radical Research and Communication, 18, pp. 195-199, (1993)
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