Rapid, Point-of-Care, Paper-Based Plasmonic Biosensor for Zika Virus Diagnosis

被引：44
作者：
Jiang Q. [1 ]
Chandar Y.J. [2 ]
Cao S. [1 ]
Kharasch E.D. [3 ,4 ]
Singamaneni S. [1 ]
Morrissey J.J. [3 ]
机构：
[1] Department of Mechanical Engineering and Materials Science, Institute of Materials Science and Engineering, Washington University in St. Louis, Saint Louis, 63130, MO
[2] The Davidson Academy of Nevada, Reno, 89507, NV
[3] Department of Anesthesiology, Siteman Cancer Center, Washington University in St. Louis, St. Louis, 63110, MO
[4] Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis, St. Louis, 63110, MO
来源：
Advanced Biosystems | 2017年 / 1卷 / 09期
基金：
美国国家科学基金会;
关键词：
metal–organic framework; plasmonic sensor; point of care; resource limited settings; Zika virus detection;
D O I：
10.1002/adbi.201700096
中图分类号：
学科分类号：
摘要：
Zika virus (ZIKV) is an increasing global health challenge. There is an urgent need for rapid, low-cost, and accurate diagnostic tests that can be broadly distributed and applied in pandemic regions. Here, an innovative, adaptable, and rapidly deployable bioplasmonic paper-based device (BPD) is demonstrated for the detection of ZIKV infection, via quantification of serum anti-ZIKV-nonstructural protein 1 (NS1) IgG and IgM. BPD is based on ZIKV-NS1 protein as a capture element and gold nanorods as plasmonic nanotransducers. The BPD displays excellent sensitivity and selectivity to both anti-ZIKV-NS1 IgG and IgM in human serum. In addition, excellent stability of BPDs at room and even elevated temperature for one month is achieved by metal–organic framework (MOF)-based biopreservation. MOF-based preservation obviates the need for device refrigeration during transport and storage, thus enabling their use in point-of-care and resource-limited settings for ZIKV surveillance. Furthermore, the versatile design (interchangeable recognition element) of BPDs more generally enables their ready adaptation to diagnose other emerging infectious diseases. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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