Nerolidol and its pharmacological application in treating neurodegenerative diseases: A review

被引：30
作者：
de Carvalho R.B.F. [1 ]
de Almeida A.A.C. [1 ]
Campelo N.B. [1 ,2 ]
Léllis D.R.O.D. [1 ,2 ]
Nunes L.C.C. [1 ,2 ]
机构：
[1] Federal University of Piauí, Teresina, CEP 64049-550, Piauí
[2] Department of Pharmacy, Federal University of Piauí, Teresina, CEP 64049-550, Piauí
来源：
de Carvalho, Rusbene Bruno Fonseca (rusbenebruno@hotmail.com) | 2018年 / Bentham Science Publishers卷 / 12期
关键词：
Alzheimer’s; Epilepsy; Nerolidol; Neurodegenerative diseases; Pharmacological application; Sesquiterpene;
D O I：
10.2174/1872208312666171206123805
中图分类号：
R96 [药理学]; R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ; 100706 ;
摘要：
Background: Research on natural bioactive compounds has increased exponentially over the last decades. The discovery of new phytochemicals that possess pharmaceutical properties is useful in the development of therapeutic alternatives. The nerolidol (3,7,11-trimetil-1,6,10-dodecatrien-3-ol or 3,7,11-trimetildodeca-1,6,10-trien-3-ol) has been extensively studied for its therapeutic potential because of its pharmacological activities in the treatment of neurodegenerative diseases. Method: All articles and patents regarding nerolidol and its pharmacological properties were revised, focusing mainly on the important properties in the treatment of neurodegenerative diseases. A thorough search in article databases (Science Direct, MEDLINE/PubMed, Scopus and Scielo) and patent database (WIPO, EPO, ESPTO, LATIPAT and INPI) was performed over the course of this study. Results: Several studies stood out for their relevance regarding the treatment of neurodegenerative diseases. Nerolidol demonstrated anticholinesterasic, antioxidant, antinociceptive, anti-inflammatory and anxiolytic activities, thus classifying it as a promising phytochemical for the development of therapeutic drugs. Conclusion: Analysis suggested that nerolidol is a promising target for new drugs and treatment of neurodegenerative diseases. © 2018 Bentham Science Publishers.
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页码：158 / 168
页数：10
相关论文
共 57 条
  • [1] Silva M.P.N., Oliveira G.L.S., Carvalho R.B.F., Et al., Antischistosomal activity of the terpene nerolidol, Molecules, 19, 3, pp. 3793-3803, (2014)
  • [2] Lapczynski A., Bhatia S.P., Letizia C.S., Api A.M., Fragrance material review on nerolidol (Isomer unspecified), Food Chem Toxicol, 46, 11, pp. S247-S250, (2008)
  • [3] McGinty D., Letizia C.S., Api A.M., Addendum to Fragrance material review on Nerolidol (Isomer unspecified), Food Chem Toxicol, 48, pp. S43-S45, (2010)
  • [4] Motl O., Trka A., Zuzammensetzung des brasilianischen vassoura-oils (Aus Baccharis dracunculifolia), Parfuem-Kosmet, 64, pp. 488-491, (1983)
  • [5] Cane D.E., Ha H., McIlwaine D.B., Pascoe K.O., The synthesis of (3R)-nerolidol, Tetrahedron Lett, 31, 52, pp. 7553-7554, (1990)
  • [6] Feitosa C.M., Feitosa D.M., Melo C.H.S., Chaves S.K., Considerações sobre a doença do Alzheimer, Plantas Medicinais E a doença De Alzheimer, pp. 59-71, (2015)
  • [7] Sperotto A.R.M., Moura D.J., Peres V.F., Et al., Cytotoxic mechanism of Piper gaudichaudianum Kunth essential oil and its major compound nerolidol, Food Chem Toxicol, 57, pp. 57-68, (2013)
  • [8] Klopell F.C., Lemos M., Sousa J.P., Et al., Nerolidol, an antiulcer constituent from the essential oil of Baccharis dracunculifolia DC (Asteraceae), Z Naturforsch C, 62, 7-8, pp. 537-542, (2007)
  • [9] Marin R., Silva G.T., Fontoura J.B., Et al., Composição química do óleo essencial obtido de Nectandra megapotamica (Spreng) Chodat et Hassler do Sul do Brasil, XXXIII Reunião Anual da Sociedade Brasileira de Química, Águas De Lindóia, Brasil, (2010)
  • [10] Sasidharan I., Nirmala M.A., Comparative chemical composition and antimicrobial activity fresh & dry ginger oils (Zingiber Officinale roscoe), Int J Curr Pharm Res, 2, 4, pp. 40-43, (2010)
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