Palladium(ii)-catalyzed stereoselective synthesis of: C-glycosides from glycals with diaryliodonium salts

被引：0

作者：

Pal, Kumar Bhaskar ^{[1
]}

Lee, Jiande ^{[1
,2
]}

Das, Mrinmoy ^{[1
]}

Liu, Xue-Wei ^{[1
]}

机构：

[1] Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore,637371, Singapore

[2] Nanyang Environment and Water Research Institute, Nanyang Technological University 1 Cleantech Loop, Singapore,637141, Singapore

来源：

Organic and Biomolecular Chemistry | 2020年 / 18卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

Sugars - Palladium compounds - Salts - Glycosylation;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

An efficient palladium(ii) mediated C-glycosylation of glycals with diaryliodonium salts is described, providing a new strategy for the synthesis of 2,3-dideoxy C-Aryl glycosides with excellent stereoselectivity. The C-glycosylation of a diverse range of glycals, including d-glucal, d-galactal, d-Allal, l-rhamnal, l-fucal, l-Arabinal, d-maltal, and d-lactal, occurred effectively and the corresponding C-glycosides were obtained in moderate to good yields. This protocol is commended as a significant addition to the field of carbohydrate chemistry due to the rich functional group compatibility, broad range of substrate scope and exceptional α-stereoselectivity. This journal is © The Royal Society of Chemistry.

引用

页码：2242 / 2251