Research Progress on the Stabilization and Targeted Delivery Carriers for Food Bioactive Compounds

被引：0

作者：

Yue, Qing ^{[1
]}

Shi, Wenpeng ^{[2
]}

Zhang, Chunyue ^{[1
]}

Li, Xing ^{[1
]}

Liu, Xiangyu ^{[1
]}

Lü, Mingchun ^{[3
]}

Zhang, Hui ^{[1
]}

Yuan, Yu ^{[1
]}

Yang, Zhi ^{[4
]}

Li, Yuan ^{[1
,3
]}

机构：

[1] Research Center of Food Colloids and Delivery of Functionality, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing

[2] Yixin Kanghua Biomedical Technology Co. Ltd., Beijing

[3] Advanced Technology Research Institute of China Agricultural University of Shenzhen, Shenzhen

[4] School of Food and Advanced Technology, Massey University, Auckland

来源：

Shipin Kexue/Food Science | 2024年 / 45卷 / 19期

关键词：

bioavailability; delivery systems; food bioactive compounds; functional foods; stabilization; targeted and controlled release;

D O I：

10.7506/spkx1002-6630-20231123-182

中图分类号：

学科分类号：

摘要：

Food bioactive compounds, such as polyphenols, carotenoids, functional proteins and unsaturated fatty acids, have been used as important ingredients of functional foods due to their diverse biological activities. However, the low aqueous solubility, poor stability and limited bioavailability of these compounds limit their applications in the food industry. The preparation of delivery carriers from natural food macromolecules offers a promising approach to enhance the solubility, stability, and bioavailability of bioactive compounds. As a novel delivery system, intelligent responsive delivery carriers enable precise targeted and controlled release of bioactive compounds, thus improving their bioavailability. In addition, the delivery carriers have the capacity to effectively improve the added nutritional value, enhance the sensory properties, and extend the shelf life of functional foods. This review summarizes the functional properties of food bioactive compounds, the challenges in their application and their steady-state delivery strategies, with a particular emphasis on the common intelligent responsive delivery carriers and their mechanisms of action. Finally, this article discusses the application of these delivery carriers in functional foods, and provides an outlook on future research on bioactive compound delivery systems. © 2024 Chinese Chamber of Commerce. All rights reserved.

引用

页码：272 / 286

页数：14

共 135 条

[1]

HU Y L, BAO C, LI D, Et al., The construction of enzymolyzed α-lactalbumin based micellar nanoassemblies for encapsulating various kinds of hydrophobic bioactive compounds, Food & Function, 10, 12, pp. 8263-8272, (2019)

[2]

CHANG R X, LIU B, WANG Q M, Et al., The encapsulation of lycopene with α-lactalbumin nanotubes to enhance their anti-oxidant activity, viscosity and colloidal stability in dairy drink, Food Hydrocolloids, 131, (2022)

[3]

ACEVEDO-FANI A, DAVE A, SINGH H., Nature-assembled structures for delivery of bioactive compounds and their potential in functional foods, Frontiers in Chemistry, 8, (2020)

[4]

GOMES R D S, ANAYA K, GALDINO A B S, Et al., Bovine colostrum: a source of bioactive compounds for prevention and treatment of gastrointestinal disorders, NFS Journal, 25, pp. 1-11, (2021)

[5]

LIU Y, SHEN N, XIN H W, Et al., Unsaturated fatty acids in natural edible resources, a systematic review of classification, resources, biosynthesis, biological activities and application, Food Bioscience, 53, (2023)

[6]

CHAI J J, JIANG P, WANG P J, Et al., The intelligent delivery systems for bioactive compounds in foods: physicochemical and physiological conditions, absorption mechanisms, obstacles and responsive strategies, Trends in Food Science & Technology, 78, pp. 144-154, (2018)

[7]

FALSAFI S R, KARACA A C, DENG L Z, Et al., Insights into whey protein-based carriers for targeted delivery and controlled release of bioactive components, Food Hydrocolloids, 133, (2022)

[8]

BAO C, JIANG P, CHAI J J, Et al., The delivery of sensitive food bioactive ingredients: absorption mechanisms, influencing factors, encapsulation techniques and evaluation models, Food Research International, 120, pp. 130-140, (2019)

[9]

GONCALVES A, ESTEVINHO B N, ROCHA F., Methodologies for simulation of gastrointestinal digestion of different controlled delivery systems and further uptake of encapsulated bioactive compounds, Trends in Food Science & Technology, 114, pp. 510-520, (2021)

[10]

DELON L, GIBSON R J, PRESTIDGE C A, Et al., Mechanisms of uptake and transport of particulate formulations in the small intestine, Journal of Controlled Release, 343, pp. 584-599, (2022)

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