TOAC: A useful Cα-tetrasubstituted α-amino acid for peptide conformational analysis by CD spectroscopy in the visible region. Part I

被引：0

作者：

机构：

[1] Bui, Tam T.T.

[2] Formaggio, Fernando

[3] Crisma, Marco

[4] Monaco, Vania

[5] Toniolo, Claudio

[6] Hussain, Rohanah

[7] Siligardi, Giuliano

来源：

Siligardi, G. | 2000年 / Royal Society of Chemistry卷

关键词：

Amino acids - Conformations - Electron spin resonance spectroscopy - Molecular structure - Phase transitions - Spectroscopic analysis - Substitution reactions;

D O I：

10.1039/a909033i

中图分类号：

学科分类号：

摘要：

Doubly labelled 4-amino-4-carboxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TOAC)-containing trichogin analogues showed a correlation between the CD intensity of the TOAC transition and their conformation. The helical-inducing property of the TOAC residue is position dependent and, apart from the N-terminal position, better than that of Aib.

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