The therapeutic action of actarit in type II collagen-induced arthritis mice and its mechanism

被引：0

作者：

Jin, Yong ^{[1
]}

Li, Jun ^{[1
]}

Zhang, Yun-Fang ^{[1
]}

Li, Chang-Yu ^{[1
]}

Xu, Shu-Yun ^{[1
]}

机构：

[1] Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China

来源：

Chinese Pharmaceutical Journal | 2001年 / 36卷 / 12期

关键词：

Antibodies; -; Immunology; Synthesis; (chemical);

D O I：

暂无

中图分类号：

学科分类号：

摘要：

OBJECTIVE: To study the therapeutic action of actarit(Acta) in type II collagen-induced arthritis(CIA) mice. METHODS: To prepare CIA mice model by C II emulsion and to observe the change of inflammatory and immune function in CIA mice treated with Acta. RESUITS: Acta (10,30,90 mg&middotkg-1 × 40 d) intragastric injection(ig) inhibited inflammatory swelling, multiple arthritis, pathologic change in ankle of CIA mice. In CIA mice, the high response of splenocytes, the increased IL-2 synthesis of CIA mice and the elevated IL-1 synthesis of PMΦ were all reduced to normal by treated with Acta (10,30,90 mg&middotkg-1). Acta (10,30,90 mg&middotkg-1 × 38 d) significantly suppressed the delayed-type hypersensitivity (DTH) reaction induced with type II collagen (C II) in CIA mice. But Acta (10,30,90 mg&middotkg-1 × 40 d) had no effect on the production of anti-C II CU antibodies in CIA mice. CONCLUSION: Acta showed therapeutic action in CIA mice which could be related to modulate cell-mediate immunity.

引用

页码：814 / 817