Neurotoxicity of fluoride: Neurodegeneration in hippocampus of female mice

被引：1
|
作者：
Bhatnagar, Maheep [1 ]
Rao, Pratima [1 ]
Jain, Sushma [1 ]
Bhatnagar, Rekha [1 ]
机构：
[1] Department of Zoology, M.L.S. University, Udaipur 313 001, India
来源：
Indian Journal of Experimental Biology | 2002年 / 40卷 / 05期
关键词：
Cells - Fluorine compounds - Optical microscopy - Potable water - Toxicity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Light microscopic study of hippocampal sub-regions demonstrated significant number of degenerated nerve cell bodies in the CA3, CA4 and dentate gyrus(Dg) areas of sodium fluoride administered adult female mice. Ultrastructural studies revealed, neurodegenrative characteristics like involution of cell membranes, swelling of mitochondria, clumping of chromatin material etc. can be observed in cell bodies of CA3, CA4 and dentate gyrus (Dg). Fluoride intoxicated animals also performed poorly in motor co-ordination tests and maze tests. Inability to perform well increased with higher fluoride concentration in drinking water.
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页码：546 / 554
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