Neurotoxicity of fluoride: Neurodegeneration in hippocampus of female mice

被引：1
|
作者：
Bhatnagar, Maheep [1 ]
Rao, Pratima [1 ]
Jain, Sushma [1 ]
Bhatnagar, Rekha [1 ]
机构：
[1] Department of Zoology, M.L.S. University, Udaipur 313 001, India
来源：
Indian Journal of Experimental Biology | 2002年 / 40卷 / 05期
关键词：
Cells - Fluorine compounds - Optical microscopy - Potable water - Toxicity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Light microscopic study of hippocampal sub-regions demonstrated significant number of degenerated nerve cell bodies in the CA3, CA4 and dentate gyrus(Dg) areas of sodium fluoride administered adult female mice. Ultrastructural studies revealed, neurodegenrative characteristics like involution of cell membranes, swelling of mitochondria, clumping of chromatin material etc. can be observed in cell bodies of CA3, CA4 and dentate gyrus (Dg). Fluoride intoxicated animals also performed poorly in motor co-ordination tests and maze tests. Inability to perform well increased with higher fluoride concentration in drinking water.
引用
收藏
页码：546 / 554
相关论文
共 50 条
  • [21] The potential roles of aluminum chloride and sodium fluoride on the neurotoxicity of the cerebral cortex, hippocampus, and hypothalamus of male rat offspring
    Kinawy, Amal A.
    JOURNAL OF BASIC AND APPLIED ZOOLOGY, 2019, 80 (1):
  • [22] Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol
    Ma, JY
    Wollmann, R
    Lindquist, S
    SCIENCE, 2002, 298 (5599) : 1781 - 1785
  • [23] Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration
    Morris, Deborah R.
    Levenson, Cathy W.
    JOURNAL OF TOXICOLOGY, 2012, 2012
  • [24] Role of miR-34c in ketamine-induced neurotoxicity in neonatal mice hippocampus
    Cao, Shu-e
    Tian, Jianmin
    Chen, Shengyang
    Zhang, Xiaoran
    Zhang, Yongqiang
    CELL BIOLOGY INTERNATIONAL, 2015, 39 (02) : 164 - 168
  • [25] Drug discovery and development: Biomarkers of neurotoxicity and neurodegeneration
    Walker, Abigail L.
    Imam, Syed Z.
    Roberts, Ruth A.
    EXPERIMENTAL BIOLOGY AND MEDICINE, 2018, 243 (13) : 1037 - 1045
  • [26] In vitro dopaminergic neurotoxicity of pesticides: a link with neurodegeneration?
    Heusinkveld, Harm J.
    van den Berg, Martin
    Westerink, Remco H. S.
    VETERINARY QUARTERLY, 2014, 34 (03) : 120 - 131
  • [27] Reversible toxicity of fluoride and aluminium in liver and gastrocnemius muscle of female mice
    Chinoy, NJ
    Patel, TN
    FLUORIDE, 1999, 32 (04) : 215 - 229
  • [28] Developmental fluoride neurotoxicity: an updated review
    Grandjean, Philippe
    ENVIRONMENTAL HEALTH, 2019, 18 (01)
  • [29] NEUROTOXICITY OF SODIUM-FLUORIDE IN RATS
    MULLENIX, PJ
    DENBESTEN, PK
    SCHUNIOR, A
    KERNAN, WJ
    NEUROTOXICOLOGY AND TERATOLOGY, 1995, 17 (02) : 169 - 177
  • [30] Developmental fluoride neurotoxicity: an updated review
    Philippe Grandjean
    Environmental Health, 18
12345