Stimuli-responsive multifunctional metal-organic framework- based injectable hydrogel for the treatment of breast cancer

被引：0
作者：
Ukani, Hiral [1 ]
Singh, Priya [2 ]
Banerjee, Monidipa [2 ]
Parsana, Nildhara [1 ]
Mehra, Sanjay [3 ,4 ]
Kumar, Arvind [3 ,4 ]
Kadam, Yogesh [2 ]
Malek, Naved [1 ]
机构：
[1] Ionic Liquids Research Laboratory, Department of Chemistry, Sardar Vallabhbhai National Institute of Technology, Surat
[2] Department of Chemistry, School of Science and Technology, Vanita Vishram Women's University, Surat
[3] Academy of Scientific and Innovative Research (AcSIR), Ghaziabad
[4] Salt and Marine Chemicals Division, CSIR-Central Salt and Marine Chemicals Research Institute, Council of Scientific and Industrial Research, G. B. Marg, Gujarat, Bhavnagar
来源：
Journal of Molecular Liquids | 2024年 / 414卷
关键词：
5-Fluoro uracil; Drug delivery; Hydrogel; Metal organic framework; MIL-100(Fe);
D O I：
10.1016/j.molliq.2024.126022
中图分类号：
学科分类号：
摘要：
In the pursuit of improved cancer treatment, the drug delivery vehicle should encapsulate and release the drug in the consistent and controlled manner at the targeted site and helps in optimizing the therapeutic results. To design similar system, in the present investigation we introduce an innovative approach of developing the hydrogels through combining MIL-100(Fe), a biocompatible metal–organic frameworks (MOFs) with the biocompatible polymers, i.e. Xanthan gum and Carbomer 940. The resulted hydrogels showcase remarkable attributes, including swelling ability, self-healing property, and injectability along with the excellent mechanical stability. Morphological analysis confirms 3-D porous structures of hydrogels that facilitates encapsulation of drug molecules within its networks. These MOF-based hydrogel stands out for its exceptional drug loading efficiency for the anticancer drug, 5-Fluorouracil (5-FU) and its ability to respond to physiological stimuli, ensuring precise and controlled drug release. These hydrogels were tested and found to be biocompatible to blood in hemolysis test and to normal human cells (HaCat) in MTT assay. Additionally, they showed great potential against cancerous cells (MCF-7), proving their effectiveness as a way to deliver drug for treating breast cancer. © 2024 Elsevier B.V.
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