Adhesion of targeted microbubbles to endothelial cells and their potential applications in diagnosis of cardiovascular diseases

被引:0
作者
Liu, Yi-Yao [1 ]
Zhang, Lie [1 ]
Xiong, Xiao-Yan [1 ]
Yang, Hong [1 ]
机构
[1] School of Life Science and Technology, University of Electronic Science and Technology of China
来源
Dianzi Keji Daxue Xuebao/Journal of the University of Electronic Science and Technology of China | 2009年 / 38卷 / 05期
关键词
Adhesion; Endothelial cells; Microbubbles; Shear stress; Ultrasound;
D O I
10.3969/j.issn.1001-0548.2009.05.019
中图分类号
学科分类号
摘要
Ultrasound and microbubbles have been widely used for diagnostic imaging in clinical fields without producing significant adverse effects for many decades. To further improve the image contrast, development of targeted microbubbles is becoming the hot subject of ultrasound medicine in recent years. The goal of this brief review is to illustrate selected examples of targeted microbubbles that have been applied to the arenas of atherosclerosis, thrombosis, and vascular biology. The adhesion interactions of targeted microbubbles- endothelial cells under shear flow are also reviewed. The overall characterization of targeted microbubbles in vitro will be helpful for the clinic applications in the future.
引用
收藏
页码:624 / 628
页数:4
相关论文
共 27 条
  • [1] Huang Y.-L., Lu T., Aging and endothelium dysfunction, Cardiovascular Diseases Advances, 28, 5, pp. 766-770, (2007)
  • [2] Ding P., Li J., The relationship of endothelium dysfunction and coronary artery disease, and its prevention advances, Journal of Practical Heart, Brain and Lung Vascular Diseases, 15, pp. 87-89, (2007)
  • [3] Vanboutte P.M., Endothelial dysfunction and atherosclerosis, Journal of European Heart, 18, pp. 19-29, (1997)
  • [4] Biegelsen E.S., Loscalzo J., Endothelial function and atherosclerosis, Coronary Artery Disease, 10, pp. 214-256, (1999)
  • [5] Taddei S., Salvetti A., Endothelial dysfunction in essential hypertension: Clinical implications, Journal of Hypertension, 20, pp. 1671-1674, (2002)
  • [6] Ley K., Tedder T.F., Leukocyte interactions with vascular endothelium: New insights into selectin-mediated attachment and rolling, Journal of Immunology, 155, pp. 525-528, (1995)
  • [7] Sheridan F.M., Cole P.G., Ramage D., Leukocyte adhesion to the coronary microvasculature during ischemia and perfusion in an in vivo canine model, Circulation2, 93, pp. 1784-1787, (1996)
  • [8] Liu Z.-H., Liu Y.-Y., Yang H., Applications of ultrasonic cavitation and ultrasound microbubbles in biomedicine and therapy, Biotechnology Letter, 5, pp. 475-478, (2008)
  • [9] Du Y.-F., Yu M., Yan Y., Advances in ultrasound microbubble materilals, Functional Materials, 35, pp. 2473-2476, (2004)
  • [10] Anderson D.R., Tsutsui J.M., Xie F., Et al., The role of complement in the adherence of microbubbles to dysfunctional arterial endothelium and atherosclerotic plaque, Cardiovascular Research, 73, pp. 597-606, (2007)