Comparison of skin autofluorescence, a marker of tissue advanced glycation end-products in the fistula and non-fistula arms of patients treated by hemodialysis

被引：0

作者：

Tangwonglert, Theerasak ^{[1
]}

Vareesangthip, Kornchanok ^{[2
]}

Vongsanim, Surachet ^{[3
]}

Davenport, Andrew ^{[4
]}

机构：

[1] Nephrology Division, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand

[2] Renal Division, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

[3] Renal Division, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

[4] UCL Department of Nephrology, Royal Free Hospital, University College London, London, United Kingdom

来源：

Artificial Organs | 2020年 / 44卷 / 11期

关键词：

Dialysis - Blood - Hemodynamics - Patient monitoring - Patient treatment - Hemodialyzers;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Advanced glycosylation end-products (AGEs) are reported to be a risk factor for cardiovascular mortality in hemodialysis (HD) patients. As serum AGEs can change with dialysis, measurement of AGEs deposited in the skin by autofluorescence (SAF) is now a recognized method of measuring AGEs. An arteriovenous fistula (AVF) is the preferred way to access blood in HD patients, and as the creation of an AVF changes blood flow distribution in the arm, we wished to determine whether this affected SAF deposition in the skin. SAF was measured using the AGE reader, which directs ultraviolet light at an intensity range of 300-420 nm (peak 370 nm) in the arms of HD patients dialyzing with an AVF. We measured SAF in 267 patients, 60.3% male, 46.1% diabetic, median duration of dialysis 34.7 (15.1-64.2) months with AVF. The median SAF was lower in the AVF arm (median 3.4 (2.9-4.2) vs. 3.7 (3.2-4.5) AU, P .05). AVF alters blood flow in the arm, and we found that SAF measurements were lower in the arm with AVF. We suggest that SAF measurements are made in the non-AVF arm. © 2020 International Center for Artificial Organs and Transplantation and Wiley Periodicals LLC

引用

页码：1224 / 1227