The protective effects of BGYH on mice acute liver injury induced by D-galn and LPS

被引：0

作者：

Dai, Rong-Ji ^{[1
]}

Su, Jing ^{[1
]}

Wang, Fei ^{[1
]}

Lin, Fan-Kai ^{[1
]}

Lü, Fang ^{[1
]}

Chen, Yan ^{[2
]}

Meng, Wei-Wei ^{[1
]}

Deng, Yu-Lin ^{[1
]}

机构：

[1] School of Life, Beijing Institute of Technology, Beijing

[2] Beijing BIT & Gen Yuan Pharmaceutical R&D Co. Ltd., Beijing

来源：

Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology | 2015年 / 35卷

关键词：

Acute liver injury; BGYH; Hepato-protective and descending transaminase function; Immune regulation;

D O I：

10.15918/j.tbit1001-0645.2015.supplement1.015

中图分类号：

学科分类号：

摘要：

In the present study, D-GalN/LPS-induced acute liver injury mice model was applied to investigate the effectiveness of hepato-protective and descending transaminase function of BGYH. ICR mice were randomly divided into seven groups: control group, model group, low-, medium- and high-dose BGYH group, silymarin group and bifendate group. All dose groups were orally administrated respective drugs once for one day and continued for 9 days while control and model groups were given equal volume of vehicle. Post the last administration, D-GalN/LPS were injected intraperitoneally into mice except control group. The results show that the levels of ALT and AST in serum are significantly reduced in high-dose BGYH group. Meanwhile, sections of liver tissue also illustrated high-dose BGYH can alleviate necrocytosis of hepatocytes. Moreover, in the mechanism study, significant reduction of TNF-α and IL-6 in serum of medium- and high- dose BGYH group is observed, and concentration of IL-10 is remarkably increased. Furthermore, declining trend of NO and iNOS concentration occures in liver tissue. In conclusion, BGYH possessed protective effects on mice acute liver injury induce by D-GalN/LPS through the immunomodulation pathway. ©, 2015, Beijing Institute of Technology. All right reserved.

引用

页码：67 / 71

页数：4

共 12 条

[1] Lian L.H., Wu Y.L., Wan Y., Et al., Anti-apoptotic activity of gentiopicroside in D-galactosamine/lipopolysaccharide-induced murine fulminant hepatic failure, Chemico-Biological Interactions, 188, 1, pp. 127-133, (2010)
[2] Olaso E., Ikeda K., Eng F.J., Et al., DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells, The Journal of Clinical Investigation, 108, 9, pp. 1369-1378, (2001)
[3] Song Z., Wu Y., Piao H., Protective effects of extracts of Inonotus obliquus on acute hepatic failure in mice, Journal of Medocal Science Yanbian University, 30, 1, pp. 34-36, (2007)
[4] Riedemann N.C., Guo R.F., Ward P.A., The enigma of sepsis, The Journal of Clinical Investigation, 112, 4, pp. 460-467, (2003)
[5] Zhang L., Li H.Z., Gong X., Et al., Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide/D-galactosamine in mice, Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, 17, 10, pp. 811-819, (2010)
[6] Zhang X., Xiao S., Rong M., Et al., Polysaccharides of dicliptera chinensis(l.)nees. alleviates liver injury of galn/lps-induce fulminant hepatitis in rats, Chinese Journal of Pathophysiology, 26, 5, pp. 952-955, (2010)
[7] Han D.W., Intestinal endotoxemia as a pathogenetic mechanism in liver failure, World Journal of Gastroenterology: WJG, 8, 6, pp. 961-965, (2002)
[8] Nowak M., Gaines G.C., Rosenberg J., Et al., LPS-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF-alpha and the TNF-p55 receptor, American Journal of Physiology Regulatory, Integrative and Comparative Physiology, 278, 5, pp. 1202-1209, (2000)
[9] Feng Y., Research progress of naturel medicine against acute liver damage, Modern Medicine & Health, 27, 21, pp. 3282-3284, (2011)
[10] Morio L.A., Chiu H., Sprowles K.A., Et al., Distinct roles of tumor necrosis factor-alpha and nitric oxide in acute liver injury induced by carbon tetrachloride in mice, Toxicology and Applied Pharmacology, 172, 1, pp. 44-51, (2001)

← 1 2 →