Carcinoembryonic antigen (CEA) and hepatic metastasis in colorectal cancer: Update on biomarker for clinical and biotechnological approaches

被引：115
作者：
Campos-Da-paz M. [1 ]
Dórea J.G. [2 ]
Galdino A.S. [1 ]
Lacava Z.G.M. [3 ]
Almeida Santos M.F.M. [3 ]
机构：
[1] Department of Biochemistry, Federal University of São João del Rei, Campus CCO, Divinópolis, MG
[2] Departmentof Nutrition, Faculty of Health Sciences, University of Brasília, Brasília-DF
[3] Department of Genetics and Morphology, Institute of Biology, University of Brasília, Brasília-DF
来源：
Recent Patents on Biotechnology | 2018年 / 12卷 / 04期
关键词：
Anti-CEA biotechnological applications; Biomarker; Carcinoembryonic antigen; CEA; Colorectal cancer; Liver metastasis;
D O I：
10.2174/1872208312666180731104244
中图分类号：
学科分类号：
摘要：
Background: Carcinoembryonic Antigen (CEA) is a recommended prognostic marker in Colorectal Cancer (CRC) for tumor diagnosis and monitoring response to therapy. High CEA levels are specifically associated with CRC progression and increased levels of the marker are expected to fall following surgical treatment. Due to its role in CRC, CEA has also been explored as a target for cancer therapy and diagnosis approaches. Objective: The goal of this work is to highlight the role of CEA in CRC progression and liver metastasis as well as its potential as a biomarker for clinical and biotechnological approaches. Method: A literature search of electronic medical and patent databases Pubmed, Scopus, and Science Direct, Google patents, Esp@cenet and United States Patent and Trademark Office (USPTO), was performed. Information was collected in recent publications, including 81 articles besides 13 patents related to different CEA targeting biotechnological approaches for CRC therapy and diagnosis. Results: CEA enhances CRC metastatic potential through many ways. CEA protects metastatic cells from death, changes the microenvironment of sinusoids, promoting the expression of adhesion molecule and malignant cell survival, besides being considered a proangiogenic molecule. Furthermore CEA has also been evaluated as a target in drug delivery systems, photodynamic therapy, radioimmunotherapy, cancer imaging and nanotechnological devices, leading to many patents concerning to development of anti-CEA antibodies or their fragments with potential to target colorectal cancer and liver metastasis cells. Conclusion: CEA is already clinically used to monitor CRC patients, and it is a very promising targeting biomarker for multiple biotechnological applications. As far as we know this is the first report on CEA that addresses patents database. © 2018 Bentham Science Publishers.
引用
收藏
页码：269 / 279
页数：10
相关论文
共 94 条
[1]  
Gold P., Freedman S.O., Specific carcinoembryonic antigens of the human digestive system, J Exp Med, 122, pp. 467-481, (1965)
[2]  
Khoo S.K., Mackay I.R., Carcinoembryonic antigen in serum in diseases of the liver and pancreas, J Clin Pathol, 26, pp. 470-475, (1973)
[3]  
Yamaguchi S., Takeuchi Y., Arai K., Et al., Elevation of carcinoembryonic antigen coinciding with disease activity of ulcerative colitis, Clin J Gastroenterol, 5, pp. 150-154, (2012)
[4]  
Lee J.-W., Park K.-D., Im J.-A., Hwang H.-J., Kim S.-H., Serum carcinoembryonic antigen is associated with metabolic syndrome in female Korean non-smokers, Clin Chim Acta, 412, pp. 527-530, (2011)
[5]  
Ochi S., Shimizu H., Ueno S., Association between high serum carcinoembryonic antigen and clinical state of male anorexia nervosa: A case report, Int J Eat Disord, 49, pp. 428-431, (2016)
[6]  
Pusztaszeri G., Mach J.-P., Carcinoembryonic Antigen (CEA) in non-digestive cancerous and normal tissues, Immunochemistry, 10, pp. 197-204, (1973)
[7]  
Baranov V., Hammarstrom S., Carcinoembryonic antigen (CEA) and CEA-related Cell Adhesion Molecule 1 (CEACAM1), apically expressed on human colonic M cells, are potential receptors for microbial adhesion, Histochem Cell Biol, 121, pp. 83-89, (2004)
[8]  
Hammarstrom S., The Carcinoembryonic Antigen (CEA) family: Structures, suggested functions and expression in normal and malignant tissues, Semin Cancer Biol, 9, pp. 67-81, (1999)
[9]  
Marshall J., Carcinoembryonic antigen-based vaccines, Semin Oncol, 30, pp. 30-36, (2003)
[10]  
Benchimol S., Fuks A., Jothy S., Beauchemin N., Shiro-Ta K., Stanners C.P., Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule, Cell, 57, pp. 327-334, (1989)
12345678910