Research Progress in the Regulation of Cellular Homeostasis and the Mechanism of Meat Color Regulation by Signal Transducer and Activator of Transcription 3

被引：0

作者：

Zhao, Wenxiu ^{[1
]}

Du, Rui ^{[2
]}

Du, Xuerong ^{[1
]}

Dong, Yushan ^{[1
]}

Li, Chenlong ^{[1
]}

Yao, Lili ^{[1
]}

Hou, Yanru ^{[1
]}

Zhang, Jing ^{[1
]}

Luo, Yulong ^{[1
]}

机构：

[1] School of Food Science and Engineering, Ningxia University, Yinchuan

[2] Yinchuan Agricultural Product Quality Testing Center, Yinchuan

来源：

Shipin Kexue/Food Science | 2024年 / 45卷 / 18期

关键词：

color stability; free radicals; mitochondrial homeostasis; myoglobin; signal transducer and activator of transcription 3;

D O I：

10.7506/spkx1002-6630-20231207-063

中图分类号：

学科分类号：

摘要：

Signal transducer and activator of transcription 3 (STAT3) exists in the cytoplasm, nucleus, mitochondria, and mitochondria associated endoplasmic reticulum membranes, which is a signal transduction protein involved in various physiological processes such as cell proliferation, differentiation, migration, and immune regulation. This article provides an overview of the structures and types of STAT3 and the pathways through which STAT3 enters mitochondria, and elaborates on the regulatory effect of STAT3 on cellular homeostasis including the anti-apoptotic effect mediated by endoplasmic reticulum Ca2+ transport, the mechanism of action in maintaining mitochondrial function, and the regulatory mechanism on lipid synthesis and catabolism. Furthermore, this paper explores the regulatory mechanism of STAT3 on meat color from the perspective of regulating hematopoietic stem cells, skeletal muscle, mitochondrial homeostasis, and lipid synthesis and metabolism in order to provide a theoretical reference for improving meat color. © 2024 Chinese Chamber of Commerce. All rights reserved.

引用

页码：242 / 249

页数：7

共 70 条

[31] XIA T T, ZHANG M, LEI W, Et al., Advances in the role of STAT3 in macrophage polarization, Frontiers in Immunology, 14, (2023)
[32] SHULGA N, PASTORINO J G., GRIM-19-mediated translocation of STAT3 to mitochondria is necessary for TNF-induced necroptosis, Journal of Cell Science, 125, pp. 2995-3003, (2012)
[33] PHILLIPS D, REILLEY M J, APONTE A M, Et al., Stoichiometry of Stat3 and mitochondrial proteins implications for the regulation of oxidative phosphorylation by protein-protein interactions, Journal of Biological Chemistry, 285, 31, pp. 23532-23536, (2010)
[34] GIORGI C, MISSIROLI S, PATERGNANI S, Et al., Mitochondria-associated membranes: composition, molecular mechanisms, and physiopathological implications, Antioxidants & Redox Signaling, 22, 12, pp. 995-1019, (2015)
[35] MARCHI S, PATERGNANI S, MISSIROLI S, Et al., Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death, Cell Calcium, 69, pp. 62-72, (2018)
[36] DANESE A, PATERGNANI S, BONORA M, Et al., Calcium regulates cell death in cancer: roles of the mitochondria and mitochondria-associated membranes (MAMs), Biochimica et Biophysica Acta, 1858, 8, pp. 615-627, (2017)
[37] SU Y X, HUANG X M, HUANG Z S, Et al., STAT3 localizes in mitochondria-associated ER membranes instead of in mitochondria, Frontiers in Cell and Developmental Biology, 8, (2020)
[38] KANIA E, ROEST G, VERVLIET T, Et al., IP<sub>3</sub> receptor-mediated calcium signaling and its role in autophagy in cancer, Frontiers in Oncology, 7, (2017)
[39] KREIMENDAHL S, RASSOW J., The mitochondrial outer membrane protein Tom70-mediator in protein traffic, membrane contact sites and innate immunity, International Journal of Molecular Sciences, 21, 19, (2020)
[40] AVALLE L, CAMPOREALE A, MORCIANO G, Et al., STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca<sup>2+</sup> fluxes and apoptotic responses, Cell Death and Differentiation, 26, 5, pp. 932-942, (2019)

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