Research Progress in the Regulation of Cellular Homeostasis and the Mechanism of Meat Color Regulation by Signal Transducer and Activator of Transcription 3

被引：0

作者：

Zhao, Wenxiu ^{[1
]}

Du, Rui ^{[2
]}

Du, Xuerong ^{[1
]}

Dong, Yushan ^{[1
]}

Li, Chenlong ^{[1
]}

Yao, Lili ^{[1
]}

Hou, Yanru ^{[1
]}

Zhang, Jing ^{[1
]}

Luo, Yulong ^{[1
]}

机构：

[1] School of Food Science and Engineering, Ningxia University, Yinchuan

[2] Yinchuan Agricultural Product Quality Testing Center, Yinchuan

来源：

Shipin Kexue/Food Science | 2024年 / 45卷 / 18期

关键词：

color stability; free radicals; mitochondrial homeostasis; myoglobin; signal transducer and activator of transcription 3;

D O I：

10.7506/spkx1002-6630-20231207-063

中图分类号：

学科分类号：

摘要：

Signal transducer and activator of transcription 3 (STAT3) exists in the cytoplasm, nucleus, mitochondria, and mitochondria associated endoplasmic reticulum membranes, which is a signal transduction protein involved in various physiological processes such as cell proliferation, differentiation, migration, and immune regulation. This article provides an overview of the structures and types of STAT3 and the pathways through which STAT3 enters mitochondria, and elaborates on the regulatory effect of STAT3 on cellular homeostasis including the anti-apoptotic effect mediated by endoplasmic reticulum Ca2+ transport, the mechanism of action in maintaining mitochondrial function, and the regulatory mechanism on lipid synthesis and catabolism. Furthermore, this paper explores the regulatory mechanism of STAT3 on meat color from the perspective of regulating hematopoietic stem cells, skeletal muscle, mitochondrial homeostasis, and lipid synthesis and metabolism in order to provide a theoretical reference for improving meat color. © 2024 Chinese Chamber of Commerce. All rights reserved.

引用

页码：242 / 249

页数：7

共 70 条

[1] LEVY D E, JR DARNELL J E., Stats: transcriptional control and biological impact, Nature Reviews Molecular Cell Biology, 3, 9, pp. 651-662, (2002)
[2] LIN L, LIU A G, PENG Z G, Et al., STAT3 is necessary for proliferation and survival in colon cancer-initiating cells, Cancer Research, 71, 23, pp. 7226-7237, (2011)
[3] YANG H, YAMAZAKI T, PIETROCOLA F, Et al., STAT3 inhibition enhances the therapeutic efficacy of immunogenic chemotherapy by stimulating type 1 interferon production by cancer cells, Cancer Research, 75, 18, pp. 3812-3822, (2015)
[4] GOUGH D J, CORLETT A, SCHLESSINGER K, Et al., Mitochondrial STAT3 supports Ras-dependent oncogenic transformation, Science, 324, 5935, pp. 1713-1716, (2009)
[5] WEGRZYN J, POTLA R, CHWAE Y J, Et al., Function of mitochondrial Stat3 in cellular respiration, Science, 323, 5915, pp. 793-797, (2009)
[6] BOENGLER K, UNGEFUG E, HEUSCH G, Et al., The STAT3 inhibitor stattic impairs cardiomyocyte mitochondrial function through increased reactive oxygen species formation, Current Pharmaceutical Design, 19, 39, pp. 6890-6895, (2013)
[7] GUADAGNIN E, MAZALA D, CHEN Y W., STAT3 in skeletal muscle function and disorders, International Journal of Molecular Sciences, 19, 8, (2018)
[8] TIERNEY M T, AYDOGDU T, SALA D, Et al., STAT3 signaling controls satellite cell expansion and skeletal muscle repair, Nature Medicine, 20, 10, pp. 1182-1186, (2014)
[9] YANG Y, DUAN W X, JIN Z X, Et al., JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury, Journal of Pineal Research, 55, 3, pp. 275-286, (2013)
[10] SALA D, SACCO A., Signal transducer and activator of transcription 3 signaling as a potential target to treat muscle wasting diseases, Current Opinion in Clinical Nutrition and Metabolic Care, 19, 3, pp. 171-176, (2016)

← 1 2 3 4 5 6 7 →