Prevalence of Interictal Epileptiform Discharges in Children Less Than One Year of Age Referred for Polysomnography

被引：0

作者：

Adeleye, Adetayo ^{[1
]}

Ho, Alice W. ^{[2
]}

Nettel-Aguirre, Alberto ^{[3
]}

Kirk, Valerie ^{[1
]}

Buchhalter, Jeffrey ^{[2
]}

机构：

[1] Section of Respiratory Medicine, Alberta Children's Hospital, Calgary, AB

[2] Section of Neurology, Alberta Children's Hospital, Calgary, AB

[3] Departments of Pediatrics and Community Health Sciences, University of Calgary, Alberta Children's Hospital Research Institute for Child and Maternal Health, Calgary, AB

来源：

Neurodiagnostic Journal | 2015年 / 55卷 / 02期

关键词：

Children; EEG; Interictal epileptiform discharges;

D O I：

10.1080/21646821.2015.1043224

中图分类号：

学科分类号：

摘要：

This study aimed to identify the prevalence of interictal epileptiform discharges (IEDs) in patients less than one year of age referred for polysomnogram (PSG), to quantify the number of IEDs and characterize sleep stage(s) during which IEDs occur, and to relate the reason for PSG referral and IED frequency. This was a retrospective cohort study of children less than 12 months of age referred for PSG studies. Fifty study participants had sufficient EEG data, and 49 were included in the study analysis. We identified an IED prevalence rate of 28% over the 2-year study period. The mean number (Standard Deviation; SD) of IEDs per hour of total sleep time was 0.4 (1.2). IEDs occurred most frequently in non-rapid eye movement (NREM) stages 2 and 3 of sleep. The most common reason for PSG referral in this patient cohort was for obstructive sleep apnea (OSA) (42/50). We concluded that patients less than 12 months of age referred for PSG may have abnormal brain activity. The relationship of that activity to PSG findings is unclear. This study offers a systematic process of identifying IEDs that should prompt referral to a neurologist for further evaluation. © ASET - The Neurodiagnostic Society.

引用

页码：122 / 132

页数：10

共 19 条

[1]

Badawy R.A., Curatolo J.M., Newton M., Berkovic S.F., Macdonell R.A., Sleep deprivation increases cortical excitability in epilepsy: Syndrome-specific effects, Neurology, 67, 6, pp. 1018-1022, (2006)

[2]

Bazil C.W., Sleep and epilepsy, Curr Opin Neurol, 13, 2, pp. 171-175, (2000)

[3]

Borusiak P., Zilbauer M., Jenke A.C., Prevalence of epileptiform discharges in healthy children-new data from a prospective study using digital EEG, Epilepsia., 51, 7, pp. 1185-1188, (2010)

[4]

Bull M.J., Health supervision for children with Down syndrome, Pediatrics, 128, 2, pp. 393-406, (2011)

[5]

Capdevila O.S., Dayyat E., Kheirandish-Gozal L., Gozal D., Prevalence of epileptiform activity in healthy children during sleep, Sleep Med, 9, 3, pp. 303-309, (2008)

[6]

Cavazzuti G.B., Cappella L., Nalin A., Longitudinal study of epileptiform EEG patterns in normal children, Epilepsia, 21, 1, pp. 43-55, (1980)

[7]

Eeg-Olofsson O., Petersen I., Sellden U., The development of the electroencephalogram in normal children from the age of 1 through 15 years, Paroxysmal Activity. Neuropadiatrie, 2, 4, pp. 375-404, (1971)

[8]

Ellingson R.J., Eisen J.D., Ottersberg G., Clinical electroencephalographic observations on institutionalized mongoloids confirmed by karyotype, Electroencephalogr Clin Neurophysiol, 34, 2, pp. 193-196, (1973)

[9]

Ferrillo F., Beelke M., Nobili L., Sleep EEG synchronization mechanisms and activation of interictal epileptic spikes, Clin Neurophysiol, 111, pp. 65-73, (2000)

[10]

Iber C., Ancoli-Israel S., Chesson A.L., Quan S.F., The AASM Manual for the Scoring of Sleep and Associated Events: Rules Terminology and Technical Specifications, (2007)

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