Synthesis of N-substituted thiazolidines and dihydrobenzothiazoles

被引：0

作者：

Katritzky, Alan R. ^{[1
]}

Singh, Sandeep K. ^{[1
]}

He, Hai-Ying ^{[1
]}

机构：

[1] Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, United States

来源：

Synthesis | 2002年 / 12期

关键词：

Nucleophilic substitutions;

D O I：

10.1055/s-2002-33636

中图分类号：

学科分类号：

摘要：

Ethyl (4R)-3-(1H-1,2,3-benzotriazol-1-ylmethyl)-1,3-thiazolane-4-carboxylate (6) and 1-[1,3-benzothiazol-3(2H)-ylmethyl]-1H-1,2,3-benzotriazole (8) were readily prepared by reactions of L-cysteine ethyl ester hydrochloride and 1-aminothiophenol with benzotriazole and formaldehyde, respectively, Chiral thiazolidine esters 7a-c were obtained by reactions of intermediate 6 with organozinc derivatives. Nucleophilic substitutions of 8 with Grignard reagents gave N-substituted dihydrobenzothiazoles 9a-c.

引用

页码：1646 / 1648