Bio-based composite hydrogels for biomedical applications

被引:43
作者
Buwalda S.J. [1 ]
机构
[1] UMR CNRS 7635, Center for Materials Forming (CEMEF), MINES ParisTech, PSL Research University, CS 10207, Sophia Antipolis
来源
Multifunctional Materials | 2020年 / 3卷 / 02期
关键词
Bio-based polymers; Biomedical; Composites; Fibers; Hydrogels; Particles;
D O I
10.1088/2399-7532/ab80d6
中图分类号
学科分类号
摘要
Hydrogels are three-dimensional, water-swollen polymer networks that have been widely studied for biomedical applications such as tissue engineering and the controlled delivery of biologically active agents. Since the pioneering work of Wichterle and Lim in the 1960s, hydrogel research has shifted from relatively simple single polymer networks to multifunctional composite hydrogels that better mimic the complex nature of living tissues. Bio-based polymers, which can be obtained from renewable natural resources, are attracting increasing attention for use in biomaterials due to the recent demands for a reduction in the environmental impact of the polymer industry and the development of a sustainable society. Moreover, bio-based polymers are often biodegradable and exhibit a significant level of biocompatibility and biomimicry, which are highly desired properties with regard to in vivo application. This review presents the state-of-the-art in the field of bio-based composite hydrogels for biomedical applications, thereby focusing on different types of polymeric components that have been combined with hydrogels to obtain materials with unique, synergistic properties: particles (including micelles and microspheres), electrospun fibres and nanocellulose. In addition, the challenges are described that should be overcome to facilitate clinical application of these versatile and environmentally responsible biomaterials. © 2020 IOP Publishing Ltd
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共 120 条
[1]  
Buwalda S J, Vermonden T, Hennink W E, Hydrogels for therapeutic delivery: current developments and future directions, Biomacromolecules, 18, pp. 316-330, (2017)
[2]  
Buwalda S J, Boere K W M, Dijkstra P J, Feijen J, Vermonden T, Hennink W E, Hydrogels in a historical perspective: from simple networks to smart materials, J. Control. Release, 190, pp. 254-273, (2014)
[3]  
Vermonden T, Klumperman B, The past, present and future of hydrogels, Eur. Polym. J, 72, pp. 341-343, (2015)
[4]  
Kopecek J, Hydrogels: from soft contact lenses and implants to self-assembled nanomaterials, J. Polym. Sci. A, 47, pp. 5929-5946, (2009)
[5]  
Hoffman A S, Hydrogels for biomedical applications, Adv. Drug Deliv. Rev, 54, pp. 3-12, (2002)
[6]  
Nakajima H, Dijkstra P, Loos K, The recent developments in biobased polymers toward general and engineering applications: polymers that are upgraded from biodegradable polymers, analogous to petroleum-derived polymers, and newly developed, Polymers, 9, (2017)
[7]  
Babu R P, O'connor K, Seeram R, Current progress on bio-based polymers and their future trends, Prog. Biomater, 2, (2013)
[8]  
Van Vlierberghe S, Dubruel P, Schacht E, Biopolymer-based hydrogels as scaffolds for tissue engineering applications: a review, Biomacromolecules, 12, pp. 1387-1408, (2011)
[9]  
Salerno A, Pascual C D, Bio-based polymers, supercritical fluids and tissue engineering, Process Biochem, 50, pp. 826-838, (2015)
[10]  
Zhao F, Yao D, Guo R, Deng L, Dong A, Zhang J, Composites of polymer hydrogels and nanoparticulate systems for biomedical and pharmaceutical applications, Nanomaterials, 5, pp. 2054-2130, (2015)