Evaluation of inflammatory processes by FTIR spectroscopy

被引：9

作者：

Rodrigues L.M. ^{[1
]}

Carvalho L.F.D.C.E.S. ^{[2
,3
]}

Bonnier F. ^{[4
]}

Anbinder A.L. ^{[1
]}

Martinho H.D.S. ^{[5
]}

Almeida J.D. ^{[1
]}

机构：

[1] Department of Bioscience and Oral Diagnosis, Institute of Science and Technology of São José dos Campos, Univ Estadual Paulista-UNESP, São José dos Campos

[2] Departamento de Odontologia, Universidade de Taubaté, Taubate

[3] Graduação em Odontologia, Universidade Braz Cubas, Mogi das Cruzes

[4] Faculty of Pharmacy, Université François-Rabelais de Tours, Tours

[5] Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo Andre

来源：

Journal of Medical Engineering and Technology | 2018年 / 42卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

diagnosis; FTIR spectroscopy; inflammatory processes;

D O I：

10.1080/03091902.2018.1470691

中图分类号：

学科分类号：

摘要：

Fourier transform infrared (FTIR) spectroscopy is a powerful diagnosis technique and has been used to identify patterns of molecular changes based on vibration modes. The objective of this study was to evaluate inflammatory fibrous hyperplasia (IFH) lesions and oral normal mucosa (NM) initially with histopathological exam and then using micro-FTIR spectroscopy to analyse the samples. Eleven IFH and 11 NM samples were analysed at five different points to cover the largest area possible by the micro-FTIR technique. Bands were observed between 970 and 1743 cm−1 which corresponded to different structural components like collagen, lipids, fatty acids, proteins and amino acids. Spectral bands were more intense mostly for IFH lesions, including collagen bands, which are an important component of inflammatory fibrous hyperplasia. This study demonstrated that differentiation in the inflammatory tissue was observed in FTIR spectral differences, in terms of biochemical composition. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

引用

页码：228 / 235

页数：7