Decoding nervous system by single-cell RNA sequencing

被引:0
作者
Ganlu Hu
Guang-Zhong Wang
机构
[1] KeyLaboratoryofComputationalBiology,ChineseAcademyofSciences-MaxPlanckPartnerInstituteforComputationalBiology,ShanghaiInstitutesforBiologicalSciences,ChineseAcademyofSciences
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D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Mammalian brain are composed of a large number of specialized cell types with diverse molecular composition, functions and differentiation potentials. The application of recently developed single-cell RNA sequencing(scRNA-seq) technology in this filed has provided us new insights about this sophisticated system,deepened our understanding of the cell type diversity and led to the discovery of novel cell types.Results: Here we review recent progresses of applying this technology on studying brain cell heterogeneity, adult neurogenesis as well as brain tumors, then we discuss some current limitations and future directions of using scRNAseq on the investagation of nervous system.Conclusions: We believe the application of single-cell RNA sequencing in neuroscience will accelerate the progress of big brain projects.
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页码:210 / 214
页数:5
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