VMAT2 Transport and Inhibition Mechanisms Revealed by Cryo-EM

<正>Neurotransmitters are a class of signaling chemicals, including monoamines such as serotonin, dopamine, and histamine, which play a vital role in a variety of neurological activities, including mood, memory, growth and development, and drug addiction. The cytosolic neurotransmitters in presynaptic neurons must be transported into synaptic vesicles for storage and subsequent release.