Ketone bodies determine the female reproductive lifespan

被引:0
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作者
Long Yan [1 ,2 ,3 ,4 ]
Hongmei Wang [1 ,2 ,3 ,4 ]
机构
[1] State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
[2] Institute for Stem Cell and Regeneration, Chinese Academy of Sciences
[3] Beijing Institute for Stem Cell and Regenerative Medicine
[4] University of Chinese Academy of
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R339.22 [];
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摘要
<正>In a recent study published in Life Metabolism,Wang and colleagues reported that the ketone body was elevated during the neonatal stage to regulate the formation of the primordial follicle pool and affect the subsequent ovarian aging through coordinating ROS-induced follicle apoptosis.Female reproduction and health are highly dependent on ovarian function.The critical indicator of ovarian function is the ovarian reserve [1],which refers to the stockpile of dormant primordial follicles (primordial follicle pool) residing in the ovarian cortex [2].The initial size of the primordial follicle pool and the rate of primordial follicle consumption determine the extent and the speed of reproductive aging [3].Extensive studies have reported multiple mechanisms whereby the formation of primordial follicle pool is regulated [4].Furthermore,increasing evidence reveals that environmental chemicals contribute to the ovarian reservoir and the reproductive lifespan [5].However,the association between surroundings and ovarian activities remains poorly understood.
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页码:101 / 102
页数:2
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