Characterization of auditory sensation in C. elegans

被引：0

作者：

Can Wang ^{[1
,2
]}

Elizabeth ARonan ^{[1
,2
]}

Adam JIliff ^{[1
]}

Rawan AlEbidi ^{[1
]}

Panagiota Kitsopoulos ^{[3
]}

Karl Grosh ^{[3
,4
]}

Jianfeng Liu ^{[5
]}

XZShawn Xu ^{[1
,2
]}

机构：

[1] Life Sciences Institute, University of Michigan

[2] Department of Molecular and Integrative Physiology, University of Michigan

[3] Department of Mechanical Engineering, University of Michigan

[4] Department of Biomedical Engineering, University of Michigan

[5] College of Life Science and Technology, Key Laboratory of Molecular Biophysics of MOE, Huazhong University of Science and Technology

来源：

Biophysics Reports | 2024年 / 10卷 / 06期

关键词：

D O I：

暂无

中图分类号：

Q437 [音感受器（听觉）];

学科分类号：

071003 ;

摘要：

Research using the model organism nematode C. elegans has greatly facilitated our understanding of sensory biology, including touch, olfaction, taste, vision and proprioception. While hearing had long been considered to be restricted to vertebrates and some arthropods, we recently discovered that C.elegans is capable of sensing and responding to airborne sound in a frequency and sound source-sizedependent manner. C. elegans auditory sensation occurs when airborne sound physically vibrates their external cuticle(skin) to activate the sound-sensitive mechanosensory FLP/PVD neurons via nicotinic acetylcholine receptors(nAChRs), triggering aversive phonotaxis behavior. Here, we report stepwise methods to characterize these three features of C. elegans auditory sensation, including sound-evoked skin vibration, neuronal activation, and behavior. This approach provides an accessible platform to investigate the cellular and molecular mechanisms underlying auditory sensation and mechanotransduction mechanisms in C. elegans.

引用

页码：351 / 363

页数：13

共 13 条

[1] Sensing of sound pressure gradients by C. elegans drives phonotaxis behavior [J].