Highly selective organic synthesis by efficient mixing in flow microreactor

The use of flow microreactors shows some advantages such as precise temperature or reaction time control. Particurally, the efficient mixing in flow microreactors often affords the unique reaction results compared to those in the conventional batch reactors, because it can be enhanced the encounter frequency of each reagent in very narrow reaction channel. Of particular, even very unstable intermediates which it is difficult to be existed in batch reactors, can be reacted with coupling partners on highly efficiency in flow microreactors. In this work, three kinds of organic reactions (1): cross-coupling reaction, (2): nucleophilic aromatic substitution reaction, (3): photocatalytic reduction reaction) were performed using flow microreactors. Every examples show the highly efficiency or highly productivity because of the specific character of flow microreactors compared to that in batch reactor. Especially, unique reactor-dependent result (different product selectivity from the batch reactor) was also observed in photoreaction. © 2021 Society of Synthetic Organic Chemistry. All rights reserved.