The individual heat exchanger network structure is basically stereotyped when it is optimized by random walk algorithm with compulsive evolution (RWCE) to a certain stage, and it is difficult to destroy or change the heat balance in the certain local optimal structure and search for better solutions. Therefore, this paper explores the characteristics of structural changes in the evolution of individuals and analyzes the keys to structural evolution. It is found that heat exchange unit has great effects on the structural evolution. Therefore, the structure-fusion strategy is proposed to organize the heat exchange units of two individuals into one structure, which could expand the evolution potentiality of individual network structure. The new individual structure is optimized by RWCE to form better configuration, through the process that all heat exchange units compete with each other and the structural evolution potentiality work at full capacity. Finally, two examples are applied to verify the effectiveness of the strategy and achieve considerable optimization results. © All Right Reserved.