Facile synthesis of GSH-triggered skeleton-cleavable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific camptothecin delivery

被引：0

作者：

Li, Jie ^{[1
]}

Yang, Yubin ^{[1
]}

Liu, Peng ^{[1
]}

机构：

[1] State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou,730000, China

来源：

European Polymer Journal | 2023年 / 196卷

关键词：

Cell proliferation - Chemotherapy - Controlled drug delivery - Dendrimers - Micelles - Musculoskeletal system - Targeted drug delivery - Tumors;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Prodrug unimolecular micelles based on dendrimers or hyperbranched polymers have attracted intense interest in tumor chemotherapy. The preparation of the former one is usually cumbersome, while the stable skeleton in the latter one restricts the drug release. Here, GSH-triggered skeleton-cleavable hyperbranched polymer prodrug was designed via a Bottom-up construction strategy, by the self-condensing vinyl polymerization (SCVP) of GSH-sensitive prodrug monomer MA-SS-CPT and PEGMA with a GSH-sensitive inimer MA-SS-Br. It could self-assemble into stable unimolecular micelles, possessing GSH-triggered drug release and disintegration of the hyperbranched skeleton. So, they showed an excellent tumor-specific CPT release in the in vitro drug release and consequently tumor-specific cytotoxicity with an enhanced tumor cell growth inhibition than the free CPT. © 2023 Elsevier Ltd

引用

共 7 条

[1] Facile synthesis of GSH-triggered skeleton-cleavable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific camptothecin delivery
Li, Jie
Yang, Yubin
Liu, Peng
EUROPEAN POLYMER JOURNAL, 2023, 196
[2] GSH-triggered disintegrable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific chemotherapy
Li, Jie
Yang, Yubin
Liu, Peng
POLYMER CHEMISTRY, 2023, 14 (30) : 3512 - 3518
[3] Facile synthesis of GSH-triggered degradable hyperbranched polymer coprodrug as unimolecular micelles for precise tumor combination chemotherapy
Li, Jie
Liu, Peng
EUROPEAN POLYMER JOURNAL, 2024, 211
[4] Design of GSH-triggered disintegrable dendritic polyurethane as bioreducible unimolecular micelles for tumor-specific chemotherapeutic drug delivery
Chen, Wei
Liu, Peng
EUROPEAN POLYMER JOURNAL, 2023, 200
[5] Facile synthesis of a hyperbranched polymer prodrug as unimolecular micelles for overcoming multidrug resistance
Li, Jie
Liu, Peng
POLYMER CHEMISTRY, 2022, 13 (10) : 1369 - 1375
[6] Facile Synthesis of a Redox-Responsive Hyperbranched Polymer Prodrug as a Unimolecular Micelle for the Tumor-Selective Drug Delivery
Li, Jie
Liu, Peng
BIOCONJUGATE CHEMISTRY, 2022, 33 (02) : 411 - 417
[7] Fluorescent turn-on carbon dot-cored pseudo unimolecular prodrug micelles for tumor-specific dual-triggered drug delivery
Pei, Mingliang
Zhao, Xiaomei
Li, Guoping
Chen, Wei
Liu, Peng
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2021, 620

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